Texture Study on Optimum Formulation of Molded Poultices

概要

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In the previous paper, the value (x_i) of the i'th physical property of a molded poultice was measured, the preference value (y_j) for the j'th textural characteristic was obtained in sensory tests, and a mathematical expression for the relation between y_j and x_i was obtained in the form of first-order regression equations with good regression coefficients. A study was performed to ascertain whether x_i is related to and can be obtained from the quantities, a_k, of components, k, in a preparation. Molded poultices of 53 formulations contaning various quantities of nine ingredients were prepared and their physical properties were measured. For seven of their properties, the relations between x_i and a_k were analyzed by stepwise multiple regression analysis and were obtained in the form of first-order regression equations with a confidence level above 95%. These relations made it possible to carry out simulation of the optimum formulations of molded poultices.One of the simulated optimum formulations showed viscoelasticity at 50℃ obeying the four-element model, whose values were dete mined from creep test data.
公益社団法人日本薬学会の論文
1986-06-25