Studies on an Emulsion Formation by Flow Jet Mixer. Comparison of Flow Jet Mixer with Agitator and Colloid-Mill on Emulsion Formation

概要

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In this study, one of the purpose is the comparison of the capabilities of machines as emulsifying equipments. The other purpose is to evaluate the stability of emulsion prepared above equipments, from the changes of turbidities in the course of time. The Flow Jet Mixer, the Agitator, and the Colloid-Mill were used as emulsifying equipments. Mixtures of n-C_7H_<16> and CCl_4 were employed as the dispersed phase. Each sample of emulsion was quickly photographed under an optical microscope, in succession, the mean length diameter and the particle size distribution were calculated. Furthermore, the shear velocity du/dx could be calculated at three emulsifying equipments. The following results were obtained : (1) The size distribution curves of emulsions prepared by Colloid-Mill and Flow Jet Mixer had a sharper and narrower shape. (2) The values of shear velocity were 6.37×10^5 at Agitator, 1.94×10^6 at Flow Jet Mixer, and 5.70×10^6 (1/sec) at Colloid-Mill, respectively, when the concentration of dispersed phase was kept at 3.55% (v/v).
公益社団法人日本薬学会の論文
1977-10-25