機械的攪拌による液-液分散(第5報)コロイドミルにおける前処理攪拌の効果

概要

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This report deals with the effect of preagitation condition on emulsifying process with colloid mill. The apparatus consists of a cylindrical vessel (d=150 mm), Rushton-type impeller (d=49 mm), and an SL-type Asahi Homogenizer. Water and a mixture of n-C_7H_<16> and CCl_4 were used as the continuous phase and dispersed phase, and Tween-20 was used as emulsifying agent. After continuous agitation for 6,20,and 60 min at the revolution of 200,330,400,530,and 660 rpm, the dispersed liquid was emulsified smaller in a colloid mill. The photographs of droplets were taken by a microscopic method. The particle size distribution was calculated and the following results were obtained. 1) Particle size distribution showed a logarithmic normal distribution in the colloid mill method. 2) With the increase of surface area on agitation process, energy efficiency of colloid mill, ηM, had a larger value. 3) Effect of preagitation was important in the colloid mill method. Summing up all experimental conditions, the optimum condition of preagitation was the revolution of 660 rpm and agitation time of 60 min.
公益社団法人日本薬学会の論文
1973-09-25