Diterpenoids. XX. Nitration of Dimethyl 1,2,3,10-Tetrahydro-4β, 10α-dimethyl-4H-fluorene-4α, 6-dicarboxylate and Its Hydrogenated Stereoisomers
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概要
- 論文の詳細を見る
Dimethyl 1,2,3,10-tetrahydro-4β, 10α-dimethyl-4H-fluorene-4α, 6-dicarboxylate and its hydrogenated stereoisomers were nitrated with conc. HNO_3-Ac_2O to give mononitro compound as a single product. Namely, ⊿^5-diester (X) was nitrated to give only 12-nitro compound (XI) and, in contrast, four possible stereoisomers due to the asymmetric centers at C-5 and C-6 of the saturated diester (XVII, XVIII, XIX, and XX) gave only 13-nitro compounds (XXI, XXII, XXIII, and XIV, respectively). Accordingly, 12-and 13-substituted (NO_2,NH_2,OH, and OMe) compound could be optionally obtained herein.
- 公益社団法人日本薬学会の論文
- 1972-08-25
著者
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田原 昭
Rikagaku Kenkyusho (The Institute of Physical and Chemical Research)
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大塚 晏央
Rikagaku Kenkyusho
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田原 昭
Rikagaku Kenkyusho (the Institute Of Physical Chemical Research)
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大塚 晏央
Rikagaku Kenkyusho (the Institute Of Physical Chemical Research)
関連論文
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- Synthesis of 6β Hydroxy-tetrahydro-and-hexahydroenantio-deoxypodocarpic Acid
- 12 A環置換天然ジテルペノイドの合成
- Diterpenoids. XIV. Conformational Studies. II. Preferred Conformation of A/B-cis Ring-C Aromatic Tricyclic Diterpenes
- Diterpenoids. IX. Chemical Conversion to Diterpene Alkaloid from Abietic Acid.
- Diterpenoids. VIII. Synthesis of Skeleton of Diterpene Alkaloid.
- Conformational Studies. I. Nuclear Magnetic Resonance Analysis on Conformation of 10β-and 10α-Oxy-enantio-deoxypodocarpic Acid Type Isomer.
- Diterpenoids. VII. Study on Catalytic Hydrogenations of Methyl 9-Oxo-10-hydroxypodocarpa-5,7,10,13-tetraen-16-oate Enantiomer Type Compounds
- Study on the Chemical Shifts for the Methyl Groups of Deoxypodocarpic Acid (Enantiomer) Type Compounds and Syntheses of their 10β-15 or 10α-17 Epoxy Derivatives
- Selective Oxidation of the C_1- or C_-Methyl Group in Antipodal Deoxypodocarpic Acid Type Compounds
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- Novel Nitration Reaction of Methyl 7-Oxodehydroabietate
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- Diterpenoids. XI. A Synthesis of Hydrofluorene Derivatives (trans-A/B-Ring Fusion (β C_5-H))
- Diterpenoids. X. A Synthesis of c-Homohydrofluorene
- Diterpenoids. XLVI. Syntheses of Taxodione, Royleanone and Their Analogues
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- Transformation of l-Abietic Acid to Benzohydroazulene Derivative
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- Conversion of Dehydroabietic Acid into a Steroid Skeleton : Formation of the D-Ring. II
- Conversion of Dehydroabietic Acid into a Steroid Skeleton : Formation of the A-ring. III.
- Conversion of Dehydroabietic Acid into a Steroid Skeleton : Formation of the A-Ring. II
- Conversion of Dehydroabietic Acid into a Steroid Skeleton : Formation of the A-Ring. I
- Study on Synthesis of Antipodal Steroid
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