Biochemical Studies on Benzoquinone Derivatives. V. Structure-Activity Relationship between Benzoquinone Derivatives and Inhibition of Respiration of Rat Liver Intact Mitochondria

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概要

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• Alkyldihydroxy-p-benzoquinone and related compounds were newly prepared and effects of these compounds on a respiration of rat liver intact mitochondria were examined. Structure activity relationship between the benzoquinone derivatives and effects on the mitochondrial respiration was discussed. 1. 2-Methyl-5-octyl-3,6-dihydroxy-1,4-benzoquinone and ardisiaquinone B showed specific inhibition of State-3 respiration. But in high concentration they inhibited both State-3 and State-4 respiration. 2. 2-Octyl-3,5-diydroxy-1,4-benzoquinone and ardisiaquinone A inhibited both State-3 and State-4 respiration. 3. Rapanone, maesaquinone, polygonaquinone and related compounds having longer alkyl chains did not show any effect. As the result carbon numbers of the side chain have been found to be an important factor to exhibit the activity.

• 公益社団法人日本薬学会の論文
• 1968-05-25

著者

• 義平 邦利

  National Institute Of Hygienic Sciences

• 百瀬 和享

  東北大学医学部薬学科

• 名取 信策

  国立衛試

• 名取 信策

  National Institute Of Hygienic Sciences:(present Address)meiji College Of Pharmacy

• 義平 邦利

  National Institute Of Hygienic Science

• 町田 征子

  Pharmaceutical Institute, Tohoku University School of Medicine

• 町田 征子

  Pharmaceutical Institute Tohoku University School Of Medicine

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