Synthesis of Pyridazine Derivatives. XIV. On the Methylation of 4-Amino-3 (2H) pyridazinone Derivatives
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概要
- 論文の詳細を見る
4-Amino-3 (2H) pyridazinone derivatives (Ia〜Id) were methylated with dimethyl sulfate in aqueous sodium hydroxide solution, yielding 2-methyl compounds (IIa〜IId) and zwitterionic 1-methyl compounds (IIIa〜IIId). The position of the methyl group of these products (II and III) was unambiguously determined. The ratio of formation of both II and III in the methylation has been found to be markedly influenced by the substituent at adjacent 6-position.
- 公益社団法人日本薬学会の論文
- 1966-10-25
著者
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三崎 敦子
Pharmaceuticals Division, Sumitomo Chemical Co., Ltd.
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村野 敦
Institute For Biological Science Sumitomo Chemical Co. Ltd.
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中込 孟也
Research Department, Pharmaceutical Division, Sumitomo Chemical Co., Ltd.
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三崎 敦子
Research Department, Pharmaceutical Division, Sumitomo Chemical Co., Ltd.
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中込 孟也
Research And Development Center Pharmaceuticals Division Sumitomo Chemical Co. Ltd.
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三崎 敦子
Pharmaceuticals Division Sumitomo Chemical Co. Ltd.
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村野 敦
Research Department, Osaka Works, Sumitomo chemical Co., Ltd.
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