Determination of Optical Isomers of Clinofibrate by High-Performance Liquid Chromatography

概要

論文の詳細を見る
A method for separation and determination of optical isomers of 2,2´-(4,4´-cyclohexylidenediphenoxy)-2,2´-dimethyldibutyric acid (clinofibrate) by high-performance liquid chromatography was developed. meso, d- and l-isomers of clinofibrate were derivatized with D-(+)-α-methylbenzylamine to the corresponding diastereomer amides, which were separated from one another by high-performance liquid chromatography. Each isomer in clinofibrate was determined. The chromatographic conditions were as follows : column, stainless-steel two connecting columns (150 mm in length and 4 mm in i.d.) packed with LiChrosorb SI-60 (5 μm) ; mobile phase, n-hexane/isopropanol (500/3,v/v) ; flow rate, 1.6 ml/min ; detector, UV photometer at 254 nm.
公益社団法人日本薬学会の論文
1979-07-25