Synthesis of Pyridazine Derivatives. XI. Synthesis of N^1-4-Pyridazinylsulfanilamide Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
Reactions of 4-amino-3,6-dichloropyridazine (I) with caustic alkali in methanol and of 4-amino-3,6-dimethoxypyridazine (III) with acetylsulfanilchloride in pyridine were studied. In the former reaction, the reaction sequence to the formation of (III), 4-amino-6-chloro-(IV) and 4-amino-6-methoxy-3(2H) pyridazinone (V) was clarified. In the latter condensation reaction, it was found by thin-layer chromatography that 2-p-acetylaminobenzenesulfonyl-5-amino-6-methoxy-3(2H) pyridazinone (XI), two demethylated compounds (IX and X) of N^1-(3,6-dimethoxy-4-pyridazinyl)-N^4-acetylsulfanilamide (VIII) as well as the main product (VIII) were produced and their structures were proved. The demethylation reactions of VIII and its deacetylated compound (XII) with pyridine hydrochloride were examined.
- 公益社団法人日本薬学会の論文
- 1966-10-25
著者
-
三崎 敦子
Pharmaceuticals Division, Sumitomo Chemical Co., Ltd.
-
小林 晃
Research Department Pharmaceutical Division Sumitomo Chemical Co. Ltd.
-
中込 孟也
Research Department, Pharmaceutical Division, Sumitomo Chemical Co., Ltd.
-
三崎 敦子
Research Department, Pharmaceutical Division, Sumitomo Chemical Co., Ltd.
-
小松 敏昭
Research Department, Pharmaceutical Division, Sumitomo Chemical Co., Ltd.
-
森 徹
Development Department, Yodogawa Pharmaceutical Co.
-
中西 清一
Development Department, Yodogawa Pharmaceutical Co.
-
中込 孟也
Research And Development Center Pharmaceuticals Division Sumitomo Chemical Co. Ltd.
-
中込 孟也
住友化学工業株式会社医薬事業部研究部
-
三崎 敦子
Pharmaceuticals Division Sumitomo Chemical Co. Ltd.
-
小松 敏昭
住友化学工業株式会社医薬事業部研究部
-
中西 清一
Development Department Yodogawa Pharmaceutical Co.
-
森 徹
Development Department Yodogawa Pharmaceutical Co.
関連論文
- 1-Acylindoles. VII. On Formation Reaction of Indoles from Phenylhydrazines with Several Acidic Catalysts
- Synthesis of Pyridazine Derivatives. XII. Reaction of Amino-3 (2H) pyridazinone Derivatives with Tosyl Chloride
- Synthesis of Pyridazine Derivatives. XI. Synthesis of N^1-4-Pyridazinylsulfanilamide Derivatives
- β-ラクタム系抗生物質の研究(第5報)6-[D(-)-α-(Acylamino)-4-hydroxyphenylacetamido]penicillanic Acid誘導体の合成と抗菌活性
- β-ラクタム系抗生物質の研究(第3報)6-[D(-)-α-(Acylamino)phenylacetamido]penicillanic Acid誘導体の合成と抗菌活性
- Synthesis of Pyridazine Derivatives. XIII. Synthesis of N^1-(2-methyl-3-oxo-2,3-dihydro-4-pyridazinyl)-sulfanilamide Derivatives.
- Conversion of Acylamidopenicillins to Phosphoramidopenicillins, and Removal of Their Phosphoryl Side Chain
- Synthesis of Pyridazine Derivatives. XIV. On the Methylation of 4-Amino-3 (2H) pyridazinone Derivatives
- Synthesis of Pyridazine Derivatives. IX. Nitration of 3,4-Dimethylpyridazine N-Oxide Derivatives.
- Synthesis of Pyridazine Derivatives. VIII. N-Oxidation of 3,4-Dimethylpyridazine Derivatives.
- Bemerkung zur Nitrierung des 1,2,3,4-Tetrahydroisochinolins und seiner Derivate.
- Uber die Umlagerung von 5-Nitroisochinolin-N-Oxyd mittels Tosylchlorids.
- Studies on the Proton Magnetic Resonance Spectra in Aromatic Systems. II. Discussions on the Polysubstituted Benzene Derivatives.