A Novel Synthesis of Benzo[c]phenanthridine Skeleton and Biological Evaluation of Isoquinoline Derivatives
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概要
- 論文の詳細を見る
Benzo[c]phenanthridine skeleton was synthesized from easily available starting N-methyl-o-toluamide 2 and o-methylbenzonitrile 5 in 7 steps. Radical cyclization of styrene 10 afforded 6,11-dimethyl-6,11 -dihydro-5H-in-deno[1,2-c]isoquinolin-5-one 13. Most 3-arylisoquinolines have displayed strong activities against human tumor cell lines. Especially, indenoisoquinolinone 13 exhibited excellent cytotoxicity (IC_<50>=0.002 μg/ml; HCT 15).
- 公益社団法人日本薬学会の論文
- 1999-06-15
著者
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Park M‐j
Chungnam National Univ. Taejon Kor
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IMANISHI Takeshi
Faculty of Pharmaceutical Sciences, Osaka University
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Imanishi Takeshi
Faculty Of Pharmaceutical Sciences Osaka University
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Chung Byung-ho
College Of Pharmacy Chonnam National University
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CHO Won-Jea
College of Pharmacy, Chonnam National University
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PARK Myun-Ji
College of Pharmacy, Chonnam National University
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Park Myun-ji
College Of Pharmacy Chonnam National University
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Cho Won-jea
College Of Pharmacy And Research Institute Of Drug Development Chonnam National University
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Cho Won-jea
College Of Pharmacy Chonnam Narional University
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- A Novel Synthesis of Benzo[c]phenanthridine Skeleton and Biological Evaluation of Isoquinoline Derivatives
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