Application of Ring-Closing Metathesis for the Synthesis of Benzo[3,4]azepino[1,2-b]isoquinolin-9-ones

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概要

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• Cycloaddition reaction between toluamides and benzonitriles was applied to prepare the 3-arylisoquinolines, and their chemical transformation to the dienes 4 was performed. The ring-closing metathesis (RCM) reaction afforded the desired heterocyclic compounds, benzo[3,4]azepino[1,2-b]isoquinolinones 5 in good yield.

• 公益社団法人　日本薬学会の論文

著者

• Le Thanh

  College Of Pharmacy And Research Institute Of Drug Development Chonnam National University

• Cho Won-jea

  College Of Pharmacy And Research Institute Of Drug Development Chonnam National University

• Van Hue

  College of Pharmacy and Research Institute of Drug Development, Chonnam National University

• Khadka Daulat

  College of Pharmacy and Research Institute of Drug Development, Chonnam National University

• Yang Su

  College of Pharmacy and Research Institute of Drug Development, Chonnam National University

• LE Thanh

  College of Pharmacy and Research Institute of Drug Development, Chonnam National University

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