Total Synthesis of Oxyfagaronine, Phenolic Benzo [c] phenanthridine and General Synthetic Way of 2,3,7,8- and 2,3,8,9-Tetrasubstituted Benzo [c] phenanthridine Alkaloids

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概要

• 論文の詳細を見る

• Benzo[c]phenanthridine alkaloids such as oxynitidine, oxysanguinarine, oxyavicine and phenolic oxyfagaro-nine were synthesized from easily available starting benzonitriles 5 and toluamides 6 using a lithiated toluamide-benzonitrile cycloaddition reaction. The coupling reaction provided 3-arylisoquinolinones that were transformed to the benzo[c]phenanthridones. This method is highly efficient and could be useful for preparing diverse substituted aromatic benzo[c]phenanthridine compounds on a multi gram scale.

• 公益社団法人日本薬学会の論文
• 2006-04-01

著者

• Le Thanh

  Coll. Of Pharmacy And Res. Inst. Of Drug Dev. Chonnam National Univ.

• Le Thanh

  College Of Pharmacy And Research Institute Of Drug Development Chonnam National University

• Cho Won-jea

  Coll. Of Pharmacy And Res. Inst. Of Drug Dev. Chonnam National Univ.

• CHO Won-Jea

  College of Pharmacy, Chonnam National University

• Cho Won-jea

  College Of Pharmacy And Research Institute Of Drug Development Chonnam National University

関連論文

• Comparative Molecular Field Analysis Study of Stilbene Derivatives Active against A549 Lung Carcinoma
• Total Synthesis of Oxyfagaronine, Phenolic Benzo [c] phenanthridine and General Synthetic Way of 2,3,7,8- and 2,3,8,9-Tetrasubstituted Benzo [c] phenanthridine Alkaloids
• A Novel Synthesis of Benzo[c]phenanthridine Skeleton and Biological Evaluation of Isoquinoline Derivatives
• First Total Synthesis of the Phenolic 7,8-Dihydro-8-oxoprotoberberine Alkaloid, Cerasonine
• Synthesis of Oxychelerythrine Using Lithiated Toluamide-Benzonitrile Cycloaddition
• Application of Ring-Closing Metathesis for the Synthesis of Benzo[3,4]azepino[1,2-b]isoquinolin-9-ones

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