First Total Synthesis of the Phenolic 7,8-Dihydro-8-oxoprotoberberine Alkaloid, Cerasonine

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概要

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• First total synthesis of the phenolic protoberberine, cerasonine, was accomplished through a coupling reaction between o-toluamide and benzonitrile. This key step provided the 3-arylisoquinoline which was then successfully converted to 7,8-dihydro-8-oxoprotoberberine through an intramolecular S_N2 reaction.

• 公益社団法人日本薬学会の論文
• 2008-07-01

著者

• Le Thanh

  College Of Pharmacy And Research Institute Of Drug Development Chonnam National University

• CHO Won-Jea

  College of Pharmacy, Chonnam National University

• Cho Won-jea

  College Of Pharmacy And Research Institute Of Drug Development Chonnam National University

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• A Novel Synthesis of Benzo[c]phenanthridine Skeleton and Biological Evaluation of Isoquinoline Derivatives
• First Total Synthesis of the Phenolic 7,8-Dihydro-8-oxoprotoberberine Alkaloid, Cerasonine
• Synthesis of Oxychelerythrine Using Lithiated Toluamide-Benzonitrile Cycloaddition
• Application of Ring-Closing Metathesis for the Synthesis of Benzo[3,4]azepino[1,2-b]isoquinolin-9-ones

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