Stereochemical Aspects during Substitution Reaction of c-4-Bromo-r-1-cyano-c-3-methoxy-1,2,3,4-tetrahydroisoquinoline Derivatives with Amines

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概要

• 論文の詳細を見る

• 2-Acyl (or sulfonyl)-c-4-bromo-r-1-cyano-t-3-methoxy-1,2,3,4-tetrahydroisoquinolines treated with primary or secondary amines are stereoselectively converted into 4-amino-1,2,3,4-tetrahydroisoquinoline derivatives in high yields. The 1,4-trans and 3,4-trans configuration of the products has been determined by X-ray crystallography. The formation of an isoquinoline o-quinone type compound 5 is suggested as an intermediate in the reaction process.

• 公益社団法人日本薬学会の論文
• 1997-09-15

著者

• HATANO Keiichiro

  Faculty of Pharmaceutical Sciences, Nagoya City University

• Hirota M

  Department Of Synthetic Chemistry Faculty Of Engineering Yokohama National University

• HATANO Keiichiro

  Graduate School of Pharmaceutical Sciences, Nagoya City University

• Sugiura M

  Research Division The Green Cross Corporation

• Hamada Y

  Faculty Of Pharmacy Meijo University

• Kurono Y

  Department Of Pharmaceutics Faculty Of Pharmaceutical Engineering Nagoya City University

• Kurono Yukihisa

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Suezawa H

  Ministry Of Education Culture Sports Science And Technology

• Hatano K

  Graduate School Of Pharmaceutical Sciences Nagoya City University

• Hatano Keiichiro

  Faculty Of Pharmaceutical Sciences Nagoya City University

• SUEZAWA Hiroko

  Instrumental Analysis Center, Yokohama National University

• SUGIURA Michiharu

  Faculty of Pharmacy, Meijo University

• ASAI Koosuke

  Faculty of Pharmacy, Meijo University

• HAMADA Yoshiki

  Faculty of Pharmacy, Meijo University

• HIROTA Minoru

  Instrumental Analytical Center, Yokohama National University

• Suezawa Hiroko

  Instrumental Analysis Center Yokohama National University

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