Fluorine-18 Labeling of Methionine Derivatives in the Presence of Xanon Difluoride
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概要
- 論文の詳細を見る
Radiofluorination of protected methionine derivatives were examined in the presence of xenon difluoride (XeF_2). The simple reaction procedure with ^<18>F-tetrabutylammonium fluoride and XeF_2 led N-Boc-methionine esters to corresponding ^<18>F-fluoromethyl thioethers. The deprotection of the obtained labeled compounds was unsuccessful. This method expands the range of target molecules that can be labeled by fluorine-18 for noninvasive clinical measurements using positron emission tomography.
- 公益社団法人日本薬学会の論文
- 1998-08-15
著者
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HATANO Keiichiro
Graduate School of Pharmaceutical Sciences, Nagoya City University
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Hatano Kentaro
Department Of Biofunctional Research National Institute For Longevity Sciences
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