Stereochemistry of c-4-Bromo-r-1-cyano-t-3-methoxy-1,2,3,4-tetrahydroisoquinolines from Isoquinoline Reissert Compounds

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概要

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• Treatment of 2-acyl (or sulfonyl)-1-cyano-1,2-dihydroisoquinolines with bromine and CH_3OH gave 2-acyl (or sulfonyl)-4-bromo-1-cyano-3-methoxy-1,2,3,4-tetrahydroisoquinolines in a highly stereoselective manner in high yields. The stereochemistry, with 1,4-cis and 3,4-trans configurations, was determined by X-ray crystallography.

• 公益社団法人日本薬学会の論文
• 1997-05-15

著者

• HATANO Keiichiro

  Faculty of Pharmaceutical Sciences, Nagoya City University

• Hirota M

  Department Of Synthetic Chemistry Faculty Of Engineering Yokohama National University

• HATANO Keiichiro

  Graduate School of Pharmaceutical Sciences, Nagoya City University

• Sugiura M

  Research Division The Green Cross Corporation

• Hamada Y

  Faculty Of Pharmacy Meijo University

• Kurono Y

  Department Of Pharmaceutics Faculty Of Pharmaceutical Engineering Nagoya City University

• Kurono Yukihisa

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Suezawa H

  Ministry Of Education Culture Sports Science And Technology

• Hatano K

  Graduate School Of Pharmaceutical Sciences Nagoya City University

• Hatano Keiichiro

  Faculty Of Pharmaceutical Sciences Nagoya City University

• SUEZAWA Hiroko

  Instrumental Analysis Center, Yokohama National University

• SUGIURA Michiharu

  Faculty of Pharmacy, Meijo University

• ASAI Koosuke

  Faculty of Pharmacy, Meijo University

• HAMADA Yoshiki

  Faculty of Pharmacy, Meijo University

• HIROTA Minoru

  Instrumental Analytical Center, Yokohama National University

• Suezawa Hiroko

  Instrumental Analysis Center Yokohama National University

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