Transport of Harman Alkaloids across Caco-2 Cell Monolayers
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概要
- 論文の詳細を見る
This study examined the intestinal transport of five harman alkaloids using the Caco-2 cell monolayer as a model of the human intestinal mucosa. Transport parameters, permeability coefficients and percent transports, were calculated and compared under identical conditions with atenolol. Permeability coefficients were also compared with the reported values for model compounds like mannitol, propranolol and glucose. Sodium fluorescein was used as the marker for paracellular leakage. These alkaloids, in the concentration range of 250-500 μM, demonstrated substantial transport across the monolayer with moderate to high efflux rates and permeability coefficients. The transport was linear with time and was concentration dependent.
- 公益社団法人日本薬学会の論文
- 2004-04-01
著者
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Khan Ikhlas
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, Univer
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Khan Ikhlas
National Cente For Natural Products Research Research Institute Of Pharmaceutical Sciences:departmen
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KHAN Shabana
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The Un
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Khan Shabana
National Center For Natural Products Research Research Institute Of Pharmaceutical Sciences School O
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ABOURASHED Ehab
Department of Pharmacognosy, College of Pharmacy, King Saud University
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WALKER Larry
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School
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Walker Larry
National Center For Natural Products Research Research Institute Of Pharmaceutical Sciences School O
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Abourashed E
Department Of Pharmacognosy College Of Pharmacy King Saud University
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Abourashed Ehab
National Center For Natural Products Research Research Institute Of Pharmaceutical Sciences And Depa
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Abourashed Ehab
Department Of Pharmacognosy And National Center For Natural Products Research Research Institute Of
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Khan Ikhlas
National Center For Natural Products Research Research Institute Of Pharmaceutical Sciences School O
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