Microbial Transformation of Kawain and Methysticin
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概要
- 論文の詳細を見る
The styryl α-pyrones, d-kawain (1) and d-methysticin (2) are two of the major kavalactone constituents of the anxiolytic herb Piper methysticum, commonly known as kava. The use of fungal models to mimic the mammalian metabolism of 1 resulted in the production of 4'-hydroxykawain (1a) from the culture broth of Cunning-hamella elegans (ATCC 9245), the same metabolite identified in rat urine. The fungus Torulopsis petrophilum (ATCC 20225) biotransformed 2 to 3'-hydroxy-4'-methoxykawain (2c) which is analogous, but not identical, to a known rat metabolite of methysticin.
- 公益社団法人日本薬学会の論文
- 2000-12-01
著者
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Khan I
National Center For Natural Products Research The University Of Mississippi:department Of Pharmacogn
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Khan Ikhlas
National Cente For Natural Products Research Research Institute Of Pharmaceutical Sciences:departmen
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Khan Ikhlas
National Center For Natural Products Research Research Institute Of Pharmaceutical Sciences And Depa
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ABOURASHED Ehab
Department of Pharmacognosy, College of Pharmacy, King Saud University
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Abourashed Ehab
National Center For Natural Products Research Research Institute Of Pharmaceutical Sciences And Depa
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