Microbial Metabolism. Part 12. : Isolation, Characterization and Bioactivity Evaluation of Eighteen Microbial Metabolites of 4′-Hydroxyflavanone
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概要
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Fermentation of 4′-hydroxyflavanone (1) with fungal cultures, Beauveria bassiana (ATCC 13144 and ATCC 7159) yielded 6,3′,4′-trihydroxyflavanone (2), 3′,4′-dihydroxyflavanone 6-O-β-D-4-methoxyglucopyranoside (3), 4′-hydroxyflavanone 3′-sulfate (4), 6,4′-dihydroxyflavanone 3′-sulfate (5) and 4′-hydroxyflavanone 6-O-β-D-4-methoxyglucopyranoside (7). B. bassiana (ATCC 13144) and B. bassiana (ATCC 7159) in addition, gave one more metabolite each, namely, flavanone 4′-O-β-D-4-methoxyglucopyranoside (6) and 6,4′-dihydroxyflavanone (8) respectively. Cunninghamella echinulata (ATCC 9244) transformed 1 to 6,4′-dihydroxyflavanone (8), flavanone-4′-O-β-D-glucopyranoside (9), 3′-hydroxyflavanone 4′-sulfate (10), 3′,4′-dihydroxyflavanone (11) and 4′-hydroxyflavanone-3′-O-β-D-glucopyranoside (12). Mucor ramannianus (ATCC 9628) metabolized 1 to 2,4-trans-4′-hydroxyflavan-4-ol (13), 2,4-cis-4′-hydroxyflavan-4-ol (14), 2,4-trans-3′,4′-dihydroxyflavan-4-ol (15), 2,4-cis-3′,4′-dihydroxyflavan-4-ol (16), 2,4-trans-3′-hydroxy-4′-methoxyflavan-4-ol (17), flavanone 4′-O-α-D-6-deoxyallopyranoside (18) and 2,4-cis-4-hydroxyflavanone 4′-O-α-D-6-deoxyallopyranoside (19). Metabolites 13 and 14 were also produced by Ramichloridium anceps (ATCC 15672). The former was also produced by C. echinulata. Structures of the metabolic products were elucidated by means of spectroscopic data. None of the metabolites tested showed antibacterial, antifungal and antiprotozoal activities against selected organisms.
- 公益社団法人 日本薬学会の論文
著者
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Khan Ikhlas
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, Univer
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Herath Wimal
National Center For Natural Products Res. The Univ. Of Mississippi
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Khan Ikhlas
National Cente For Natural Products Research Research Institute Of Pharmaceutical Sciences:departmen
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MIKELL Julie
National Center for Natural Products Research, The University of Mississippi
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Mikell Julie
National Center For Natural Products Research The University Of Mississippi
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Khan Ikhlas
National Center for Natural Products Research, The University of Mississippi
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