Microbial Metabolism. Part 6. Metabolites of 3- and 7-Hydroxyflavones
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概要
- 論文の詳細を見る
Fermentation of 3-hydroxyflavone (1) with Beauveria bassiana (ATCC 13144) yielded 3, 4'-dihdroxyflavone (3), flavone 3-O-β-D-4-O-methylglucopyranoside (4) and two minor metabolites. 7-Hydroxyflavone (2) was transformed by Nocardia species (NRRL 5646) to 7-methoxyflavone (5) whilst Aspergillus alliaceus (ATCC 10060) converted it to 4', 7-dihydroxyflavone (6). Flavone 7-O-β-D-4-O-metylglucopyranoside (7) and 4'-hydroxyflavone 7-O-β-D-4-O-methylglucopyranoside (8) were the metabolic products of 7-hydroxyflavone (2) when fermented with Beauveria bassiana (ATCC 7159). One of the minor metabolites of 3-hydroxyflavone (1) was tentatively assigned a β'-chalcanol structure (9). Compounds 4, 7 and 8 are reported as new compounds. Structure elucidation of the metabolites was based on spectroscopic data.
- 社団法人日本薬学会の論文
- 2006-03-01
著者
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Ferreira Daneel
National Center For Natural Products Research The University Of Mississippi:department Of Pharmacogn
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Khan Ikhlas
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, Univer
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Khan I
National Center For Natural Products Research The University Of Mississippi:department Of Pharmacogn
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Herath Wimal
National Center For Natural Products Res. The Univ. Of Mississippi
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Khan Ikhlas
National Cente For Natural Products Research Research Institute Of Pharmaceutical Sciences:departmen
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Hale Amber
National Center For Natural Products Research The University Of Mississippi
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MIKELL Julie
National Center for Natural Products Research, The University of Mississippi
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Mikell Julie
National Center For Natural Products Research The University Of Mississippi
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