Reverse-phase HPLC Determination and Pharmacokinetic Study of Vanillic Acid in the Plasma of Rats Treated with the Traditional Chinese Medicinal Preparation Di-Gu-Pi Decoction
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概要
- 論文の詳細を見る
A sensitive, simple, and accurate method for the determination and pharmacokinetic study of vanillic acid in rat plasma was developed using reverse-phase HPLC with UV detection after oral administration of the traditional Chinese medicine preparation of the Di-Gu-Pi decoction. Plasma samples taken from rats were extracted with methanol. The constituent vanillic acid was separated on a C_<18> stationary phase and a mobile phase of acetonitrile-water (15:85, v/v) (adjusted to pH 3.0 using phosphoric acid), with a UV detector setting at 260 nm. The validated HPLC method developed was used to determine the pharmacokinetic profile of vanillic acid in rat plasma after administration of the Di-GuPi decoction.
- 公益社団法人日本薬学会の論文
- 2004-07-01
著者
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JIA Ying
School of Pharmacy, Shenyang Pharmaceutical University
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BI Kaishun
Shenyang Pharmaceutical University
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Li K
Shenyang Pharmaceutical University
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Jia Ying
School Of Pharmacy Shenyang Pharmaceutical University
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Bi Kaishun
School Of Pharmacy Shenyang Pharmaceutical University
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CHEN XiaoHui
School of Pharmacy, Shenyang Pharmaceutical University
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Li Kang
Shenyang Pharmaceutical University
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CHEN Xiaohui
Shenyang Pharmaceutical University
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JIA Ying
Shenyang Pharmaceutical University
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Chen Xiaohui
School Of Pharmacy Shenyang Pharmaceutical Univ.
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