Changes in mRNA Expression of Nicotinic Acetylcholine Receptor Subunits during Embryonic Development of Mouse Masseter Muscle(Developmental Biology)
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概要
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Nicotinic acetylcholine receptors (nAChRs) switch from the embryonic-type (α_2βγδ subunits) to the adult-type (α_2βεδ subunits), and disappear besides the neuromuscular junctions with the development of trunk and limb skeletal muscles. However, little is known about this process during the embryonic development of masseter muscle. To identify the time course of the nAChR transition from embryonic day (E) 11 to the newborn stage in mouse masseter muscle, we analyzed the expression level of δ, ε, and γ subunit mRNAs by competitive polymerase chain reaction in combination with reverse transcription as well as distribution of δ subunit protein by immunohistochemistry. The nAChR δ subunit mRNA was initially detected at E11, showed an approximately 25-fold increase (p<0.0001) between E11 and E17, and plateaued thereafter until the newborn stage. Immunostaining for δ subunit was observed in the whole portions of masseter myofibers at E17 and birth, suggesting that the nAChR elimination does not begin even at the newborn stage. The ε subunit mRNA initially appeared at E17, and increased in quantity by 144% (p<0.0001) up to the newborn stage. The quantity of γ subunit mRNA increased by approximately 240% (p<0.0001) between E11 and E17, and then decreased by 22% (p<0.05) from E17 value at the newborn stage. The beginning of the expression of the ε subunit mRNA was coincident with the beginning of the decrease in the quantity of the γ subunit mRNA, suggesting that the nAChR subunit switch begins at E17.
- 社団法人日本動物学会の論文
- 2002-02-25
著者
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Saito Takashi
Department of Child Health, Institute of Clinical Medicine, University of Tsukuba
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Saeki Yasutake
Department of Physiology, Dental School, Tsurumi University
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Saeki Yasutake
Departments Of Physiology Tsurumi University School Of Dental Medicine
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Saeki Yasutake
Department Of Physialogy Tsurumi Univ. School Of Dental Medicine
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NAKAGAWA YOICHI
Department of Ophthalmology and Visual Science, Tohoku University Graduate School of Medicine
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Nakagawa Yoichi
Department Of Ophthalmology And Visual Science Tohoku University Graduate School Of Medicine
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Yamane Akira
Department of Pharmacology, Tsurumi University School of Dental Medicine
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Ohnuki Yoshiki
Departments of Physiology, Tsurumi University School of Dental Medicine
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Yamane A
Department Of Pharmacology Tsurumi University School Of Dental Medicine
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Yamane Akira
Department Of Biophysics Tsurumi University School Of Dental Medicine
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Ohnuki Yoshiki
鶴見大学 歯学部生理学
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Ohnuki Yoshiki
Department Of Physiology Tsurumi University School Of Dental Medicine
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Ohnuki Yoshiki
Departments Of Physiology Tsurumi University School Of Dental Medicine
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Yamane Akira
Tsurumi Univ. School Of Dental Medicine Yokohama Jpn
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Nakagawa Yukiko
Department Of Biology Faculty Of Science Okayama University
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Saito Takashi
Second Department Of Oral And Maxillofacial Surgery Tsurumi University School Of Dental Medicine
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Saito Takashi
Department Of Applied Chemistry Faculty Of Engineering Gunma University
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Saito Takashi
Department Of Agronomy Faculty Of Agriculture Tohoku University
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Saeki Yasutake
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
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