Pharmacological Stimulation of Type 5 Adenylyl Cyclase Stabilizes Heart Rate Under Both Microgravity and Hypergravity Induced by Parabolic Flight
スポンサーリンク
概要
- 論文の詳細を見る
We previously demonstrated that type 5 adenylyl cyclase (AC5) functions in autonomic regulation in the heart. Based on that work, we hypothesized that pharmacological modulation of AC5 activity could regulate the autonomic control of the heart rate under micro- and hypergravity. To test this hypothesis, we selected the approach of activating AC5 activity in mice with a selective AC5 activator (NKH477) or inhibitor (vidarabine) and examining heart rate variability during parabolic flight. The standard deviation of normal R-R intervals, a marker of total autonomic variability, was significantly greater under micro- and hypergravity in the vidarabine group, while there were no significant changes in the NKH477 group, suggesting that autonomic regulation was unstable in the vidarabine group. The ratio of low frequency and high frequency (HF) in heart rate variability analysis, a marker of sympathetic activity, became significantly decreased under micro- and hypergravity in the NKH477 group, while there was no such decrease in the vidarabine group. Normalized HF, a marker of parasympathetic activity, became significantly greater under micro- and hypergravity in the NKH477 group. In contrast, there was no such increase in the vidarabine group. This study is the first to indicate that pharmacological modulation of AC5 activity under micro- and hypergravity could be useful to regulate the autonomic control of the heart rate.
- 2012-08-20
著者
-
Bai Yunzhe
Cardiovascular Research Institute Yokohama City University School Of Medicine
-
OKUMURA Satoshi
Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine
-
Sato Motohiko
Cardiovascular Research Institute Yokohama City University
-
Shiozawa Kouichi
Department of Physiology, Tsurumi University School of Dental Medicine
-
Ishikawa Yoshihiro
Cardiovascular Research Institute Department Of Cell Biology And Molecular Medicine University Of Me
-
Kurotani Reiko
Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine
-
Jiao Qibin
Cardiovascular Research Institute Yokohama City University Graduate School Of Medicine
-
Kurotani Reiko
Cardiovascular Research Institute Yokohama City University Graduate School Of Medicine
-
Ohnuki Yoshiki
Department Of Physiology Tsurumi University School Of Dental Medicine
-
Okumura Satoshi
Cardiology Center Chiba-hokusoh Hospital Nippon Medical School
-
Jin Meihua
Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine
-
Shiozawa Kouichi
Department Of Physiology Tsurumi University School Of Dental Medicine
-
Fujita Takayuki
Cardiovascular Research Institute Yokohama City University Graduate School Of Medicine
-
Yokoyama Utako
Cardiovascular Research Institute Yokohama City University
-
Tsunematsu Takashi
Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Japan
-
Mototani Yasumasa
Department of Physiology, Tsurumi University School of Dental Medicine, Japan
-
Cai Wenqian
Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Japan
-
Jin Hui-Ling
Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Japan
-
Ichikawa Yasuhiro
Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Japan
-
Suita Kenji
Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Japan
-
Iwatsubo Kousaku
Cardiovascular Research Institute, Department of Cell Biology & Molecular Medicine and Medicine (Cardiology), New Jersey Medical School of UMDNJ, USA
-
SATO Motohiko
Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine
-
CAI Wenqian
Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine
-
IWATSUBO Kousaku
Cardiovascular Research Institute, Department of Cell Biology & Molecular Medicine and Medicine (Cardiology), New Jersey Medical School of UMDNJ
-
JIN Hui-Ling
Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine
-
SUITA Kenji
Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine
-
MOTOTANI Yasumasa
Department of Physiology, Tsurumi University School of Dental Medicine
-
ICHIKAWA Yasuhiro
Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine
-
TSUNEMATSU Takashi
Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine
関連論文
- OE-254 Overexpression of ATRAP(AT1 receptor-assosiated protein) in cardiomyocytes completely inhibits cardiac hypertrophy induced by Angiotensin(Cardiac hypertrophy, basic/clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of th
- A case of giant coronary artery aneurysm and literature review
- New Aspects for the Treatment of Cardiac Diseases Based on the Diversity of Functional Controls on Cardiac Muscles : Effects of Targeted Disruption of the Type 5 Adenylyl Cyclase Gene
- PJ-002 Relationship between Foci of Arrhythmia and Low Voltage Zone Depicted by Dynamic Substrate Map in Patients with RVOT VPC(PJ001,Arrhythmia, Others (Clinical/Pathophysiology) 1 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The J
- PJ-783 Catheter ablation for atrial fibrillation targeting atrial areas showing complex fractionated atrial electrogram after extensive ipsilateral pulmonary vein isolation(Arrhythmia, therapy(17)(A),Poster Session(Japanese),The 72nd Annual Scientific Mee
- PJ-695 Optimizing VV Delay by Three-Dimentional Echocardiography(Heart failure, clinical(19)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-075 Does Cardiac Resynchronization Therapy Improve Heart Rate-Dependent Ventricular Performance in Patients with Impaired Cardiac Function and Left Bundle Branch Block?(Cardiac function, basic/clinical(02)(M),Oral Presentation(Japanese),The 72nd Annual
- PJ-481 C-Reactive Protein May be Absorbed through Yellow Plaque and Lead to the Formation of Vulnerable Plaque(Atherosclerosis, clinical-11 (H) PJ81,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Socie
- PE-163 Malondialdehyde-modified LDL (MDA-LDL) is a Novel Marker as Instability of Coronary Plaque : Angioscopic Analysis(Atherosclerosis, clinical-7 (H) PE28,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulati
- The Relation Between No-Reflow Phenomenon and Thombus Characteristics in Patients with Acute Coronary Syndrome(Visualization of Vulnerable Plaque (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Angioscopic Follow-Up Study of Coronary Ruptured Plaques in Non-Culprit Lesions(Visualization of Vulnerable Plaque (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-465 Type 5 Adenylyl Cyclase Hampers Desensitization of cAMP Signal to Attenuate Akt Signal and Myocyte Viability in the Heart(Heart failure, basic-3 (M) PE78,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circul
- Relationship between Physical Properties of a Food Bolus and Initiation of Swallowing
- Relationship between Physical Properties of a Food Bolus and the Swallowing Threshold during Mastication of Gel Type Food
- Food Bolus Texture and Tongue Activity Just before Swallowing in Human Mastication
- Influence of Ingested Food Texture on Jaw Muscle and Tongue Activity during Mastication in Humans
- PE-063 Oxygenation Promotes Calcium-dependent Smooth Muscle Cell Migration in the Rat Ductus Arteriosus(PE011,Congenital Heart Disease (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-319 Adenylyl Cyclase Type 6, but not Type 2 and 5, Selectively Promotes cAMP-dependent Vascular Remodeling in Rat Ductus Arteriosus(OE54,Congenital Heart Disease/Kawasaki's Disease (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of T
- PJ-432 Rising Oxygen Tension Promoted Smooth Muscle Cell Migration in the Rat Ductus Arteriosus(Congenital heart disease/Kawasaki's disease(02)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-013 Typpe 5 adenylyl cyclase plays a major role in regulating autonomic responsse to microgravity in the heart(Autonomic nervous system(02)(H),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-078 Cardiac Overexpression of Epac1 in Transgenic Mice Protects Heart from Lipopolysaccharide-induced Cardiac Dysfunction and inhibits JAK-STAT pathway(Heart failure, basic(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Jap
- OE-158 Epac1 Promotes Intimal Cushion Formation of the Rat Ductus Arteriosus by Enhancing Smooth Muscle Cell Migration(Congenital heart disease/Kawasaki's disease-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-081 T-type Calcium Channels Regulate Oxygen-induced Vascular Contraction and Smooth Muscle Cell Migration in the Rat Ductus Arteriosus(Molecular Biology in Cardiovascular Diseases (basic), The 71st Annual Scientific Meeting of the Japanese Circulation
- 5 Vascular Injury-induced Upregulation of Epac1 Counteracts PKA, Promoting Smooth Muscle Cell Migration and Neointimal Thickening(The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Type 5 Adenylyl Cyclase is Preferentially Coupled to β1-adrenoceptor Subtype in Cardiomyocytes(Cardiac Function, Basic/Clinical 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Effects of Chronic Beta-Adrenergic Receptor Stimulation in Type 5 Adenylyl Cyclase-Null Mice(Heart Failure, Basic 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-094 β-adrenergic and Muscarinic Regulation of the Heart Requires Type 5 Adenylyl Cyclase(Autonomic Nervous System 1 (H) : PE16)(Poster Session (English))
- OE-109 Disruption of the Type 5 Adenylyl Cyclase Gene Preserves Cardiac Function Against Pressure Overload(Heart Failure, Basic 1 (M) : OE13)(Oral Presentation (English))
- OE-321 Identification of a Novel G-protein Activator Induced by Cardiac Ischemia/hypoxia(Molecular biology, myocardium-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Significance of Plaque Disruption Site in Acute Coronary Syndrome (Acute Coronary Syndrome, Basic/Clinical 7 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- 2P-145 プロテインキナーゼAが心筋単一筋原線維の横弾性に与える影響(筋肉(筋蛋白質・収縮),第46回日本生物物理学会年会)
- Changes in mRNA Expression of Nicotinic Acetylcholine Receptor Subunits during Embryonic Development of Mouse Masseter Muscle(Developmental Biology)
- FRS-074 Activation of Epac1-specific Signaling Protects Heart from Cytokine-mediated Cardiac Dysfunction through the Inhibition of Proinflamatory Cytokine Signaling(FRS15,Novel Molecular Mechanisms of Heart Failure 1 (M),Featured Research Session (English
- Phosphorylation Status of Regulatory Proteins and Functional Characteristics in Myocardium of Dilated Cardiomyopathy of Syrian Hamsters
- Effects of Clenbuterol and Cyclosporin A on the Myosin Heavy Chain mRNA Level and the Muscle Mass in Rat Masseter
- Transverse Stiffness of Myofibrils of Skeletal and Cardiac Muscles Studied by Atomic Force Microscopy
- Effects of Bite-Opening and Cyclosporin A on the mRNA Levels of Myosin Heavy Chain and the Muscle Mass in Rat Masseter
- FRS-018 The Type 5 Adenylyl Cyclase Mediates Ca^-mediated Regulation of Ca^ channels in the Heart(Cardiac Hypertrophy (M) : FRS3)(Featured Research Session (English))
- Adenylyl Cyclase Type 5 Disruption Prolongs Longevity and Protects the Heart Against Stress
- Adenylyl Cyclase Type 5 Disruption Prolongs Longevity and Protects the Heart against Stress(Special Lecture 2,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-541 Roles of Ischemia-Inducible G-protein Activator, Activator of G-protein Signaling 8 : Regulation of Apoptosis and Connexin 43 of Cardiomyocytes(PE091,Molecular Biology (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese
- PE-336 A Novel G-protein Activator is Involved in Hypoxia-Induced Apoptosis of Cardlomyocyte(Heart failure, basic(03)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Apoptosis in Heart Failure : The Role of the β-Adrenergic Receptor-Mediated Signaling Pathway and p53-Mediated Signaling Pathway in the Apoptosis of Cardiomyocytes
- Effects of Addition of Water on Masticatory Behavior and the Mechanical Properties of the Food Bolus
- DNA microarray profiling identified a new role of growth hormone in vascular remodeling of rat ductus arteriosus
- Reflex Responses in the Frog Extrinsic Tongue Muscle Elicited by Stimulation of Hypoglossal Afferent Fibers
- Pharmacological Stimulation of Type 5 Adenylyl Cyclase Stabilizes Heart Rate Under Both Microgravity and Hypergravity Induced by Parabolic Flight
- Fragmentation of a Viscoelastic Food by Human Mastication
- Effect of ascorbic acid on reactive oxygen species production in chemotherapy and hyperthermia in prostate cancer cells
- Inhibition of Phosphodiesterase Type 3 Dilates the Rat Ductus Arteriosus Without Inducing Intimal Thickening
- Pharmacological Stimulation of Type 5 Adenylyl Cyclase Stabilizes Heart Rate Under Both Microgravity and Hypergravity Induced by Parabolic Flight
- Regulation of vascular tone and remodeling of the ductus arteriosus
- Effects of Chronic Akt/mTOR Inhibition by Rapamycin on Mechanical Overload–Induced Hypertrophy and Myosin Heavy Chain Transition in Masseter Muscle
- Effects of neomycin on the lateral-line organ of the mudpuppy.
- Electrical phenomenon in rabbit papillary muscle during Ba++-induced contracture.
- Effects of Protein Kinase A on the Phosphorylation Status and Transverse Stiffness of Cardiac Myofibrils
- Role of Masseter Muscle β2-Adrenergic Signaling in Regulation of Muscle Activity, Myosin Heavy Chain Transition, and Hypertrophy