Inhibition of Phosphodiesterase Type 3 Dilates the Rat Ductus Arteriosus Without Inducing Intimal Thickening
スポンサーリンク
概要
- 論文の詳細を見る
Background: Prostaglandin E1 (PGE1), via cAMP, dilates the ductus arteriosus (DA). For patients with DA-dependent congenital heart disease (CHD), PGE1 is the sole DA dilator that is used until surgery, but PGE1 has a short duration of action, and frequently induces apnea. Most importantly, PGE1 increases hyaluronan (HA) production, leading to intimal thickening (IT) and eventually DA stenosis after long-term use. The purpose of this study was therefore to investigate potential DA dilators, such as phosphodiesterase 3 (PDE3) inhibitors, as alternatives to PGE1. Methods and Results: Expression of PDE3a and PDE3b mRNAs in rat DA tissue was higher than in the pulmonary artery. I.p. milrinone (10 or 1mg/kg) or olprinone (5 or 0.5mg/kg) induced maximal dilatation of the DA lasting for up to 2h in rat neonates. In contrast, vasodilation induced by PGE1 (10μg/kg) was diminished within 2h. No respiratory distress was observed with milrinone or olprinone. Most important, milrinone did not induce HA production, cell migration, or proliferation when applied to cultured rat DA smooth muscle cells. Further, high expression of both PDE3a and PDE3b was demonstrated in the human DA tissue of CHD patients. Conclusions: Because PDE3 inhibitors induced longer-lasting vasodilation without causing apnea or HA-mediated IT, they may be good alternatives to PGE1 for patients with DA-dependent CHD. (Circ J 2012; 76: 2456–2464)
- 2012-09-25
著者
-
Sato Motohiko
Cardiovascular Research Institute Yokohama City University
-
Ikeda Yasuhiro
Cardiovascular Research Institute Yokohama City University Graduate School Of Medicine
-
Yokoyama Utako
Cardiovascular Research Institute Yokohama City University Graduate School Of Medicine
-
Iwamoto Mari
Department Of Pediatrics Yokohama City University
-
Iwamoto Mari
Department Of Cardiovascular Medicine Yokohama City University Medical Center
-
Ishikawa Yoshihiro
Cardiovascular Research Institute Department Of Cell Biology And Molecular Medicine University Of Me
-
Asou Toshihide
Department Of Cardiovascular Surgery Kanagawa Children's Medical Center
-
Yokota Shumpei
Department Of Pediatrics
-
Okumura Satoshi
Cardiology Center Chiba-hokusoh Hospital Nippon Medical School
-
Masuda Munetaka
Department Of Cardiovascular Surgery Kyushu University Hospital
-
Yokota Shumpei
Department Of Hematology/oncology Kyoto Prefectural University Of Medicine
-
Yokoyama Utako
Cardiovascular Research Institute Yokohama City University
-
Ichikawa Yasuhiro
Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Japan
-
Okumura Satoshi
Cardiovascular Research Institute Yokohama City University School Of Medicine
-
OSHIKAWA Jin
Medical Science and Cardiorenal Medicine, Yokohama City University
-
ICHIKAWA Yasuhiro
Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine
関連論文
- OE-254 Overexpression of ATRAP(AT1 receptor-assosiated protein) in cardiomyocytes completely inhibits cardiac hypertrophy induced by Angiotensin(Cardiac hypertrophy, basic/clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of th
- Long-Term Electrocardiographic Follow-up From Childhood of an Adult Patient With Brugada Syndrome Associated With Sick Sinus Syndrome : A Case Report
- A case of giant coronary artery aneurysm and literature review
- New Aspects for the Treatment of Cardiac Diseases Based on the Diversity of Functional Controls on Cardiac Muscles : Effects of Targeted Disruption of the Type 5 Adenylyl Cyclase Gene
- PJ-002 Relationship between Foci of Arrhythmia and Low Voltage Zone Depicted by Dynamic Substrate Map in Patients with RVOT VPC(PJ001,Arrhythmia, Others (Clinical/Pathophysiology) 1 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The J
- PJ-783 Catheter ablation for atrial fibrillation targeting atrial areas showing complex fractionated atrial electrogram after extensive ipsilateral pulmonary vein isolation(Arrhythmia, therapy(17)(A),Poster Session(Japanese),The 72nd Annual Scientific Mee
- PJ-695 Optimizing VV Delay by Three-Dimentional Echocardiography(Heart failure, clinical(19)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-075 Does Cardiac Resynchronization Therapy Improve Heart Rate-Dependent Ventricular Performance in Patients with Impaired Cardiac Function and Left Bundle Branch Block?(Cardiac function, basic/clinical(02)(M),Oral Presentation(Japanese),The 72nd Annual
- Prevalence of Right Bundle-Branch Block and Right Precordial ST-Segment Elevation (Brugada Type ECG) in Japanese Children
- Surgical Application for a Prolapse of the Anterior Mitral Leaflet by Replacing Artificial Chordae with Polytetrafluoroethylene Grafts
- Acute Type A Aortic Dissection Involving the Left Main Trunk of the Coronary Artery : A report of Two Successful Cases
- One and a Half Ventricle Repair for Ebstein's Anomaly
- PJ-481 C-Reactive Protein May be Absorbed through Yellow Plaque and Lead to the Formation of Vulnerable Plaque(Atherosclerosis, clinical-11 (H) PJ81,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Socie
- PE-163 Malondialdehyde-modified LDL (MDA-LDL) is a Novel Marker as Instability of Coronary Plaque : Angioscopic Analysis(Atherosclerosis, clinical-7 (H) PE28,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulati
- The Relation Between No-Reflow Phenomenon and Thombus Characteristics in Patients with Acute Coronary Syndrome(Visualization of Vulnerable Plaque (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Angioscopic Follow-Up Study of Coronary Ruptured Plaques in Non-Culprit Lesions(Visualization of Vulnerable Plaque (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-465 Type 5 Adenylyl Cyclase Hampers Desensitization of cAMP Signal to Attenuate Akt Signal and Myocyte Viability in the Heart(Heart failure, basic-3 (M) PE78,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circul
- Long-term Follow-up of Busulfan, Etoposide, and Nimustine Hydrochloride (ACNU) or Melphalan as Conditioning Regimens for Childhood Acute Leukemia and Lymphoma
- Successful Bone Marrow Transplantation for Severe Aplastic Anemia in a Patient with Persistent Human Parvovirus B19 Infection
- Mother-to-Infant Transmission of Hepatitis C Virus in Human Immunodeficiency Virus-Coinfected Mother : A Case Report
- PE-063 Oxygenation Promotes Calcium-dependent Smooth Muscle Cell Migration in the Rat Ductus Arteriosus(PE011,Congenital Heart Disease (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-319 Adenylyl Cyclase Type 6, but not Type 2 and 5, Selectively Promotes cAMP-dependent Vascular Remodeling in Rat Ductus Arteriosus(OE54,Congenital Heart Disease/Kawasaki's Disease (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of T
- PJ-432 Rising Oxygen Tension Promoted Smooth Muscle Cell Migration in the Rat Ductus Arteriosus(Congenital heart disease/Kawasaki's disease(02)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-013 Typpe 5 adenylyl cyclase plays a major role in regulating autonomic responsse to microgravity in the heart(Autonomic nervous system(02)(H),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-078 Cardiac Overexpression of Epac1 in Transgenic Mice Protects Heart from Lipopolysaccharide-induced Cardiac Dysfunction and inhibits JAK-STAT pathway(Heart failure, basic(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Jap
- OE-158 Epac1 Promotes Intimal Cushion Formation of the Rat Ductus Arteriosus by Enhancing Smooth Muscle Cell Migration(Congenital heart disease/Kawasaki's disease-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-081 T-type Calcium Channels Regulate Oxygen-induced Vascular Contraction and Smooth Muscle Cell Migration in the Rat Ductus Arteriosus(Molecular Biology in Cardiovascular Diseases (basic), The 71st Annual Scientific Meeting of the Japanese Circulation
- 5 Vascular Injury-induced Upregulation of Epac1 Counteracts PKA, Promoting Smooth Muscle Cell Migration and Neointimal Thickening(The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-551 Adenylyl Cyclase Type 2 and 5/6 Differently Regulate Vascular Tone and Remodeling in the Rat Ductus Arteriosus(Congenital heart disease/Kawasaki's disease-2 (M) PE94,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Jap
- OJ-202 The Prostaglandin E Specific-receptor EP4 Plays an Essential Role in Hyaluronan-induced Neointimal Formation in Ductus Arteriosus(Congenital heart disease/Kawasaki's disease-1 (M) OJ34,Oral Presentation (Japanese),The 70th Anniversary Annual Scient
- A Novel Alternatively Spliced Variant of the Voltage-dependent Calcium Channel α 1C Isoform in the Rat Vascular and Airway Smooth Muscles (Vascular Smooth Muscle 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Adenylyl Cyclase Type II Stimulation Inhibited Indomethacin-induced Contraction of Vascular Smooth Muscle in the Rat Ductus Arteriosus(Congenital Heart Disease/Kawasaki's Disease 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Societ
- Type 5 Adenylyl Cyclase is Preferentially Coupled to β1-adrenoceptor Subtype in Cardiomyocytes(Cardiac Function, Basic/Clinical 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Effects of Chronic Beta-Adrenergic Receptor Stimulation in Type 5 Adenylyl Cyclase-Null Mice(Heart Failure, Basic 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-094 β-adrenergic and Muscarinic Regulation of the Heart Requires Type 5 Adenylyl Cyclase(Autonomic Nervous System 1 (H) : PE16)(Poster Session (English))
- OJ-015 Retinoic acid and thyroid hormones play an important role in the transcriptional regulation of sarcolipin(Excitation-Contraction Coupling/Ion Channel (A) : OJ3)(Oral Presentation (Japanese))
- OE-109 Disruption of the Type 5 Adenylyl Cyclase Gene Preserves Cardiac Function Against Pressure Overload(Heart Failure, Basic 1 (M) : OE13)(Oral Presentation (English))
- Grade I Lymphomatoid Granulomatosis with Increased Uptake of [^F] Fluorodeoxyglucose in Positron Emission Tomography : A Case Report
- Successful Treatment of Adrenocortical Carcinoma with Pulmonary Metastasis in a Child : Report of a Case
- -1039-ELECTROCARDIOGRAPHIC FINDINGS OF FASCICULOVENTRICULAR CONNECTION DIAGNOSED FROM HEALTHY QV1 STUDENTS : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- OE-321 Identification of a Novel G-protein Activator Induced by Cardiac Ischemia/hypoxia(Molecular biology, myocardium-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Surgical Treatment of an Infant with Myocardial Ischemia Due to an Anomalous Origin of the Right Coronary Artery from the Main Pulmonary Artery : Report of a Case
- Bland-White-Garland syndrome with ventricular septal defect : late presentation
- Mechanical Cardiac Support System for Patients with Postcardiotomy Cardiogenic Shock : Analysis of Risk Factors for Survival
- Limiting Factors in Bloodless Open-Heart Surgery in Children
- -0327-EXERCISE-INDUCED NONSUSTAINED VENTRICULAR TACHYCARDIA IN THE YOUNG
- Ventricular Tachycardia in Patients Late after Repair of Tetralogy of Fallot : A Multicenter Study
- A Conformationally Controlled Regioselective Rearrangement of 2-Substituted 1-Alkynylcyclopropanols to 2-Cyclopenten-1-ones via Hexacarbonyldicobalt Complex
- OJ-172 Assesment of Ventricular Tortional Deformation in Single Right Ventricle by Two-Dimensional Ultrasound Speckle Tracking Imaging(Echo/Doppler-4 (I) OJ29,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circ
- Response of the Stroke Volume and Blood Pressure of Young Patients With Nonobstructive Hypertrophic Cardiomyopathy to Exercise
- Idiopathic sustained left ventricular tachycardia in pediatric patients
- Successful Blade Atrial Septostemy in a Patient With Severe Primary Pulmonary Hypertension : A Case Report
- PJ-180 Usefulness of Fasudil, a Rho-Kinase Inhibitor, to Treat Intractable Severe Vasopasm After Coronary Artery Bypass Surgery(Cardiovascular Surgery/CABG 2 (IHD) : PJ31)(Poster Session (Japanese))
- Significance of Plaque Disruption Site in Acute Coronary Syndrome (Acute Coronary Syndrome, Basic/Clinical 7 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- 0840 THE RELATIONSHIP BETWEEN QT INTERVAL AND RR INTERVAL IN YOUNG PATIENTS WITH FAMILIAL LONG QT SYNDROME DURING HOLTER ECG RECORDING
- Pharmacological Inhibition of Cardiac Adenylyl Cyclase in an Isoform-Specific Manner
- Calcium plays a major role in caveolin-mediated inhibition of growth signal in the heart
- Sarcolipin, a Novel Calcium Regulator, Is Preferentially Expressedin the Atrium and Is Downregulated in the Hypertrophic Heart
- Calcium cycling defects and cardiomyopathy
- -P16- PLATELET ALPHA-2 ADRENOCEPTORS IN PATIENTS WITH ANGINA PECTORIS : Coronary Thrombosis : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- A Case of Synchronous Combined Cholangiocellular and Hepatocellular Carcinoma Observed after Resection of Intraductal Papillary-mucinous Tumor
- Lung Cancer Associated with Sweet's Syndrome : Report of a Case
- OJ-022 Sarcalumenin Plays a Critical Role in SERCA2a Stability and Adaptation to Sustained Biomechanical Stresses in the Failing Heart(Heart failure, basic-2 (M) OJ4,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japane
- Sarcalumenin Deficiency Induced Cardiac Dysfunction in Mice(Excitation-contraction Coupling/Ion Channel 1 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Intravenous methylprednisolone pulse therapy for children with autoimmune hepatitis
- Usefulness of eosinophilic cationic protein as a marker of eosinophilic myocarditis in a child
- OJ-018 Left-sided Pressure Overload Down-regulated the Expression of Sarcolipin mRNA Preferentially in the Left Atrium(Excitation-Contraction Coupling/Ion Channel (A) : OJ3)(Oral Presentation (Japanese))
- -P105-LOCALIZATION OF ALPHA 1 AND ALPHA 2 ADRENOCEPTORS IN THE HUMAN KIDNEY : Hypertension : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Methotrexate for the treatment of juvenile idiopathic arthritis : process to approval for JIA indication in Japan
- Proposal for juvenile idiopathic arthritis guidance on diagnosis and treatment for primary care pediatricians and nonpediatric rheumatologists (2007)
- Toxic epidermal necrolysis in a child successfully treated with cyclosporin A and methylprednisolone
- Different patterns of cytokines, ECP and immunoglobulin profiles at two adverse drug reactions in a patient
- Intravenous gamma-globulin therapy improves hypercytokinemia in the acute phase of Kawasaki disease
- Efficacy of plasma exchange therapy for Kawasaki disease intractable to intravenous gamma-globulin
- Altered Platelet α_2-Adrenoceptors in Patients With Ischemic Heart Disease
- MEASUREMENT OF DIASTOLIC PRESSUREVOLUME RELATIONSHIPS OF IN VIVO HEARTS : A NEW METHOD FOR ESTIMATING LEFT VENTRICULAR VOLUME : Ventricular Function : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Calcium-Alkali Syndrome-Like Symptoms Manifested by Daily Alphacalcidol and Thiazide
- Guidelines on the use of etanercept for juvenile idiopathic arthritis in Japan
- Pharmacokinetics, efficacy, and safety of short-term (12 weeks) etanercept for methotrexate-refractory polyarticular juvenile idiopathic arthritis in Japan
- FRS-074 Activation of Epac1-specific Signaling Protects Heart from Cytokine-mediated Cardiac Dysfunction through the Inhibition of Proinflamatory Cytokine Signaling(FRS15,Novel Molecular Mechanisms of Heart Failure 1 (M),Featured Research Session (English
- Long-term remission in three patients with childhood-onset systemic lupus erythematosus
- Mizoribine as an effective combined maintenance therapy with prednisolone in child-onset systemic lupus erythematosus
- Acute pancreatitis associated with systemic lupus erythematosus: Successful treatment with plasmapheresis followed by aggressive immunosuppressive therapy.
- D-galactosamine/Lipopolysaccharide による肝障害モデルで cytochrome c はミトコンドリアから細胞質そして循環血液中へ移行する
- FRS-018 The Type 5 Adenylyl Cyclase Mediates Ca^-mediated Regulation of Ca^ channels in the Heart(Cardiac Hypertrophy (M) : FRS3)(Featured Research Session (English))
- Adenylyl Cyclase Type 5 Disruption Prolongs Longevity and Protects the Heart Against Stress
- Adenylyl Cyclase Type 5 Disruption Prolongs Longevity and Protects the Heart against Stress(Special Lecture 2,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-541 Roles of Ischemia-Inducible G-protein Activator, Activator of G-protein Signaling 8 : Regulation of Apoptosis and Connexin 43 of Cardiomyocytes(PE091,Molecular Biology (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese
- PE-336 A Novel G-protein Activator is Involved in Hypoxia-Induced Apoptosis of Cardlomyocyte(Heart failure, basic(03)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Ischemic Heart Attacks Following Cessation of Aspirin before Coronary Artery Bypass Surgery : A Report of Two Cases
- Apoptosis in Heart Failure : The Role of the β-Adrenergic Receptor-Mediated Signaling Pathway and p53-Mediated Signaling Pathway in the Apoptosis of Cardiomyocytes
- DNA microarray profiling identified a new role of growth hormone in vascular remodeling of rat ductus arteriosus
- Device Closure of Atrial Septal Defect : Immediate and Mid-Term Results
- Pharmacological Stimulation of Type 5 Adenylyl Cyclase Stabilizes Heart Rate Under Both Microgravity and Hypergravity Induced by Parabolic Flight
- Effect of ascorbic acid on reactive oxygen species production in chemotherapy and hyperthermia in prostate cancer cells
- Inhibition of Phosphodiesterase Type 3 Dilates the Rat Ductus Arteriosus Without Inducing Intimal Thickening
- Pharmacological Stimulation of Type 5 Adenylyl Cyclase Stabilizes Heart Rate Under Both Microgravity and Hypergravity Induced by Parabolic Flight
- Regulation of vascular tone and remodeling of the ductus arteriosus
- Surgical management of muscular trabecular ventricular septal defects
- Catheter-related Bacteremia Caused by Agrobacterium radiobacter in a Hemodialysis Patient