Endothelin-1 Causes Aggregation of Pigment in Teleostean Melanophores
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概要
- 論文の詳細を見る
In many species of teleosts, and in zebrafish (Brachydanio rerio) in particular, endothelin-1 (ET-1) caused aggregation of pigment within melanophores in a dose-dependent manner. ET-1 appeared to act directly on the melanophores since denervated melanophores responded to the peptide quite similarly to the normally innervated cells. Alpha-adrenergic blockers, namely, phentolamine and tolazoline, and a muscarinic cholinergic blocker, scopolamine, did not interfere with the action of ET-1 on melanophores. Contrary to our expectations, BQ-123, an inhibitor of mammalian ET-1 receptors (ET_A receptors), did not block the action of ET-1 on melanophores. Presumably, teleostean ET receptors have very different pharmacological characteristics from those of mammalian species. In many fishes, ET may be involved in the subtle and delicate modification of hues and patterns of the integument that are associated with their elaborate and effective chromatic strategies for survival.
- 社団法人日本動物学会の論文
- 1993-10-15
著者
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Fujii Ryozo
Department of Biomolecular Science, Faculty of Science, Toho University
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Fujii Ryozo
Department Of Biology Faculty Of Science Toho University
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Hayashi Hiroshi
Department of Biomolecular Science, Faculty of Science, Toho University
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TANAKA Yukiko
Department of Biochemical Science & Technology, Faculty of Agriculture, Kagoshima University
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Hayashi H
Department Of Basic Technics And Facilities Tokyo Metropolitan Institute For Neuroscience
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Tanaka Y
National Inst. Agrobiological Sci. Ibaraki Jpn
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