多発性硬化症 : 臨床病型,病態解析の現状と治療法(<特集>免疫性神経疾患とアフェレシス,新しい展望)

概要

論文の詳細を見る
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) with multiple lesions in time and space. MS is classified into clinical subtypes, such as relapsing-remitting MS (RRMS), primary progressive (PP) and secondary progressive (SP) MS, benign MS and malignant MS. In Japan, the classification based on the lesion distribution is also commonly used. There are two subtypes in this classification, conventional MS (CMS), in which demyelinating plaques are disseminated within CNS, and optic spinal MS (OSMS), or relapsing neuromyelitis optica (RNMO), characterized by the selective involvement of the optic nerves and spinal cord. Clinical manifestations, MRI findings of the clinical subtypes and their pathogeneses were summarized with emphasis on the unique features of Japanese MS. Immunological therapies for MS currently available in Japan were also reviewed briefly.
日本アフェレシス学会の論文
2004-10-31