視神経脊髄炎(NMO)のアフェレシス療法

概要

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Neuromyelitis optica (NMO) is an inflammatory disease of the central nervous system, characterized by severe optic neuritis and myelitis. The pathogenesis of NMO has been regarded as an astrocytopathy mediated by autoantibodies against aquaporin 4 (AQP4), a water channel protein densely expressed in astrocytic endfeet, in combination with activated complements. Therapeutic apheresis in NMO has been utilized as a treatment for acute exacerbation. In this article, we review therapeutic apheresis for NMO in terms of application, methods, and practical examples. The effectiveness of plasma exchange (PE) was reported in several retrospective studies and one prospective study. Applications of double filtration plasmapheresis (DFPP) have been reported recently. The applications of other apheresis methods or combination therapy with other biological agents are to be verified.
日本アフェレシス学会の論文
2013-10-31