Expression of Cytokeratin No. 8 in Cervical Squamous Intraepithelial Lesions with Human Papilloma Virus Infection
スポンサーリンク
概要
- 論文の詳細を見る
The objective of this study is to confirm the relationship between expression of cytokeratin no. 8 (CK8) and types of human papillomavirus (HPV) DNA in cervical squamous intraepithelial lesions (SIL). Expression of CK8, and types of HPV DNA as 6/11, 16/18 and 31/33/51 were investigated in normal and SIL tissues by immunohistochemistry and in situ hybridization techniques. CK8 positive staining was detected in 68 (51.9%) out of 131 tissues of HPV DNA positive (p < 0.01). The located patterns of CK8 were A-type (only basal layer), B-type (basal to intermediate layers), and C-type (all layers). In 54 tissues of HPV 16/18 types,there were 20 (37%) tissues that showed C-type (p < 0.001). In HPV 6/11 and 31/33/51 types, CK8 positive staining was mostly shown in A-type. The malignant transformed tissues were detected as HPV 16/18 types and CK8 C-type. HPV 16/18 types promote expression of CK8. Tissues expressed as C-type with HPV 16/18 types signify abnormal cytodifferenciation and are probably real pre-malignant lesions. The detection of CK8 and HPV DNA types are useful for prediction of malignant transformation.
- 日本組織細胞化学会の論文
著者
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FUJII Masahiko
Department of Radiology, Kobe University Graduate School of Medicine
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Oda M
Organized Center Of Clinical Medicine International University Of Health And Welfare
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Ogi Mariko
Laboratory Of Pathology Kitasato Institute Medical Center Hospital
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Fujii Masahiko
Department Of Pathology Kyorin University School Of Health Science
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TAKEDA Tomoko
Department of Tissue and Organ Development, Regeneration, and Advanced Medical Science, Gifu Univers
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Fujii Masahiko
Department Of Pathology School Of Health Sciences Kyorin University
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Oda Mizue
Organized Center Of Clinical Medicine International University Of Health And Welfare
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Takeda Tomoko
Department Of Gynecology Tokyo Metropolitan Cancer Detection Center
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Kohri Shuichi
Department of Cytology, School of Health Sciences, Kyorin University
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Oda Mizue
Department of Gynecology, Tokyo Metropolitan Cancer Detection Center
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Yanagisawa Yataro
Department of Gynecology, Tokyo Metropolitan Cancer Detection Center
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Ohmura Mineo
Department of Gynecology, Tokyo Metropolitan Cancer Detection Center
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Shiina Yoshio
Department of Cytology, School of Health Sciences, Kyorin University
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Ohmura Mineo
Department Of Gynecology Tokyo Metropolitan Cancer Detection Center
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Shiina Yoshio
Department Of Cytology Kyorin University School Of Health Science
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Kohri Shuichi
Department Of Cytology School Of Health Sciences Kyorin University
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Takeda Tomoko
Department Of Food Production Science Obihiro University Of Agriculture And Veterinary Medicine
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Yanagisawa Yataro
Department Of Gynecology Tokyo Metropolitan Cancer Detection Center
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Takeda Tomoko
Department Of Anesthesiology Sapporo Medical University School Of Medicine
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Shiina Y
Department Of Cytology School Of Health Sciences Kyorin University
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Kohri S
Department Of Cytology School Of Health Sciences Kyorin University
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