冠動脈硬化症に対するLDLアフェレシスの効果(<特集>血管病変とアフェレシス)

概要

論文の詳細を見る
The efficacy and safety of a therapeutic tool which directly removes LDL particles from circulation (LDL apheresis) have already been established for lowering cholesterol in patients with refractory hypercholesterolemia, such as homozygous familial hypercholesterolemia. Previous angiographic studies have demonstrated that regular LDL apheresis therapy has favorable effects on the progression of coronary atherosclerosis ; excellent long-term follow-up results for patients with coronary artery disease who have been treated with LDL apheresis using dextran sulfate cellulose columns plus adjunctive cholesterol-lowering drug therapy. Since the mechanisms of clinical improvement caused by LDL apheresis extend beyond the simple and drastic reduction of LDL cholesterol, further investigations about the kind of subjects or of coronary lesions, which are the best candidate for LDL apheresis, are needed.
日本アフェレシス学会の論文
2003-05-31