Effect of selective damage to cochlear outer hair cells on alternating current induced otoacoustic emissions
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概要
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The relationship between alternating current(AC)-induced otoacoustic emissions(OAEs)and the cochlear outer hair cells(OHCs)was examined. Injection of an AC into the scala media of the guinea pig cochlea, together with simultaneous stimulationby a pure tone, induced sound emissions in the ear canal at the frequencies of the AC and intermodulation distortion products. Amplitude of these emissions changed depending on the frequency of the injected AC or stimulating tone. The amplitude and its frequency dependence were decreased by selective damage to OHCs by ototoxic agents, and the decrease depended on the extent of the OHC damage, especially at the AC injection site. It is suggested that OHC acts as an electromechanical transducer in the cochlea and is responsible for the generation of the AC-induced OAEs. A nonlinearity to produce the intermodulation distortion was more susceptible to the OHC damage than the electromechanical transducing process.
- 社団法人日本音響学会の論文
著者
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Murata K
Electrotechnical Laboratory
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Murata K
Department Of Material Science Graduate School Of Science Osaka City University
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Murata Keizo
Osaka City University
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MURATA Kazuhiro
Electrotechnical Laboratory
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Murata Kazuhiro
Department Of Physics Division Of Material Science Nagoya University
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Murata K
Tokyo Medical And Dental Univ. Tokyo Jpn
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Murata Keiichi
Department Of Neurophysiology Medical Research Institute Tokyo Medical And Dental University
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Murata Keiichi
Department Of Clinical Oncology Institute Of Development Aging And Cancer Tohoku University
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Homma Tomoo
Department Of Environmental System Science Faculty Of Risk And Crisis Management Chiba Institute Of
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Homma Tomoo
Department Of Neurophysiology Medical Research Institute Tokyo Medical And Dental University
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Hosokawa Yutaka
Department of Neurophysiology,Medical Research Institute,Tokyo Medical and Dental University
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Moriyama Toshio
Department of Neurophysiology,Medical Research Institute,Tokyo Medical and Dental University
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Moriyama Toshio
Department Of Neurophysiology Medical Research Institute Tokyo Medical And Dental University
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Hosokawa Y
Department Of Neurophysiology Medical Research Institute Tokyo Medical And Dental University
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Hosokawa Yutaka
Department Of Biophysical Engineering Faculty Of Engineering Science Osaka University
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Homma Tomoo
Department Of Biotechnology Maebashi Institute Of Technology
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