Ca^<2+> Inhibits the Association of Memantine with N-Methyl-D-aspartate (NMDA) Receptor-Gated Ion Channels(Pharmacognosy)
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概要
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We examined the effect of 1-amino-3, 5-dimethyladamantane (memantine) and(+)-5-methyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5, 10-imine (MK-801) on the inhibition of [^3H] MK-801 binding to crude synaptic membranes of rat forebrains in the absence or presence of Ca^<2+>. Ca^<2+> decreased the potency of memantine to inhibit [^3H] MK-801 binding. The effect of Ca^<2+> was apparently competitive with memantine and was not annulled by the addition of Mg^<2+>. Ca^<2+> slightly enhanced [^3H] MK-801 binding, but showed no effect on the displacement of [^3H] MK-801 binding by MK-801. The Ca^<2+>-sensitive interaction of memantine with N-methyl-D-aspartate (NMDA) receptor-gated ion channels may provide a clue to understanding its voltage-dependent and clinically tolerated character.
- 公益社団法人日本薬学会の論文
- 2008-09-01
著者
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Iida Hirokazu
Laboratory Of Organic Chemistry Faculty Of Pharmaceutical Science Chiba Institute Of Science
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MORI Masahiro
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd.
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Kimura Ikuo
Laboratory Of Applied Pharmacology Faculty Of Pharmaceutical Science Chiba Institute Of Science
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Hamana Hiroshi
Laboratory Of Organic Chemistry Faculty Of Pharmaceutical Science Chiba Institute Of Science
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FUJIMOTO Masafumi
Laboratory of Applied Pharmacology, Faculty of Pharmaceutical Science, Chiba Institute of Science
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HOMMA Tomoo
Department of Environmental System Science, Faculty of Risk and Crisis Management, Chiba Institute o
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Homma Tomoo
Department Of Environmental System Science Faculty Of Risk And Crisis Management Chiba Institute Of
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Fujimoto Masafumi
Laboratory Of Applied Pharmacology Faculty Of Pharmaceutical Science Chiba Institute Of Science
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Mori Masahiro
Laboratory Of Applied Pharmacology Faculty Of Pharmaceutical Science Chiba Institute Of Science
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Mori Masahiro
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
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Homma Tomoo
Department Of Biotechnology Maebashi Institute Of Technology
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