アンドロゲンの前立腺に対する作用機序に関する研究 : 第III編合成ゲスターゲン剤の抗アンドロゲン効果 : (附)Chloromadinone acetateによる前立腺肥大症治験

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1. Chloromadinone acetate was administered to castrated rats which were concomitantly treated with testosterone, and anti-androgenic effect of chloromadinone acetate was observed as inhibition of prostatic growth evoked by testosterone. 2. Anti-androgenic effect by chloromadinone acetate seems to be one tenth of that by cyproterone acetate in rat ventral prostate. 3. The activity of 5α-reductase in benign prostatic hypertrophy seems to be rather high, however, that in prostatic cancer was significantly reduced. 4. Treatment of 36 cases of benign prostatc hypertrophy with chloromadinone acetate, daily dose of which were 25-600mg, revealed improvements of chief complaints and regressive change of prostatic size. These effects were obtained after several weeks from start of treatment, and on 12 weeks after onset of administration most cases showed objective improvements in urethrogram and palpation size. In cases performed prostatectomy after drug administration, atrophy of glands and increase of connective tissue was observed in prostatic specimens.
社団法人日本泌尿器科学会の論文