アンドロゲンの前立腺に対する作用機序に関する研究 : 第II編エストロゲンのTestosterone-5α-reduction抑制効果 : (附)Estradiol diphophateによる前立腺癌治験

概要

論文の詳細を見る
1. The activity of 5α-reductase from prostate was inhibited in vitro by supplementing the estrogenic compounds. Estradiol-17β showed the strongest inhibitory effect among tested samples. 2. Administration with estradiol-17βdiphosphate in vivo revealed a rather weak estrogenic effect, however, this compound showed significant inhibition of 5α-reductase when added to incubation medium of prostatic slices. 3. Treatment of 8 cases of prostatic cancer was performed with a daily dose of 100 mg of estradiol-17βdiphosphate which was injected intramuscularly 30-65 times. The results of the treatment were very satisfactory and tumor-regressive effect was observed in all cases. No serious side-ffect was observed during and after treatment except slight changes of the mammary gland seen in all cases.
社団法人日本泌尿器科学会の論文