1 ステロイド・核酸代謝の見地からみたアンドロゲンの作用機序の解明

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Many works on actions of androgen to rat ventral prostate demonstarted that testoosterone increased RNA and protein syntheiss promptly after administration of testosterone. Before RNA synthesis was increased by testosterone, the fluctuation of ATP was noticed in ventral prostate. Increase of DNA syntheiss needed the lag time after testosterone in jection, and this increase was temporary.<BR>Rat ventral prostate possessed 5a-reductase and 17-hydroxysteroid dehydrogenase of testosterone. The rate of 5a-reduction of testosterone was influenced by endogenous and exogenous testosterone level, but the rate of 17-dehydrogenation of testosterone was constant in various experimental conditions (Endocrinol. Jap. 16,453, 1969). The localization of 5a-reductase of testosterone was investigated by different centrifugation. Microsomal fraction contained about half of the content of RNA and more than half of the whole ATPase activity, however, the activity of 5a-reductase was appeared in some part. This results suggested some relationship between the presence of 5a-reductase and nuclear constituents.<BR>The activity of 5a-reductase was found in human skin, and activity in scrotal skin was higher than that in abdominal part. This results suggested the importance of the role of 5a-reduction of testosterone in the hormonal action.
日本内分泌学会の論文