前立腺癌の電顕像に及ぼす去勢の影響

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Prostatic cancer cells are known to be shrunken after castration or antiandrogenic treatment. In this paper electron micrographs of normal prostate, benign prostatic hypertrophy, prostatic cancer cells and castrated prostatic cancer cells were demonstrated. Specimens were obtained from 3 healthy persons, 3 cases with benign prostatic hypertrophy and 8 cases with prostatic cancer. In cases of prostatic cancer, the pictures of cancer cell were compared before and after castration. In normal prostatic gland, tall columnar epithelia developed well. These cells were separated from stroma by a basement membrane. Along the basement membrane, basal cells were scattered, which appeared to have no secretory function. In glandular cells, round or oval nuclei were present at the basal region. Endoplasmic reticulum, mitochondria, secretory granules and vacuoles were observed in the cytoplasm. In benign prostatic hypertrophy internal structures of the cell did not differed significantly from those in normal prostate. As to cancer cells it was sometimes difficult to differentiate malignant cells from normal ones. However, the most prominent feature of prostatic cancer cell was shown by changes of nuclei which were featured by irregularity of the nuclear membrane and increases in number and size of nucleic chromatins. Numerous cytoplasmic organelles, especially endoplasmic reticulum and mitochondria were seen to be scattered in the cytoplasm. Prostatic cancer cells were observed to destroy the basement membrane and invade into the surrounding connective tissue. The most evident effect of castration on the cancer cells was collapse of endoplasmic reticulum and mitochondria, and degeneration of the cancer cell at the end stadium. Numerous cytoplasmic inclusion bodies were seen, which appeared to be transformed from mitochondria and endoplasmic reticulum. After castration, mature and immature collagen fibers were noted throughout the prostatic tissue around the fibroblast. These findings are considered to be the effect of castration.
社団法人日本泌尿器科学会の論文

前立腺癌の電顕像に及ぼす去勢の影響

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