化学療法剤の効果判定基準について

概要

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Evaluating the clinical effect of a chemotherapeutics for infection statistically, a point system was employed. For, it could be totalized many clinical data readily and accurately by employing this system. However, being difficult to evaluate the effect of a drug for urinary infection which had obstructive factor in the urinary tract, only cases of acute cystitis were selected as materials. Rules of this system were as follows; 1) Leukocytes and bacilli in urine and subjective symptoms were estimated as a rate of 3:2:1 respectively. 2) When these three factors were present at first visit, twelve points were given independing of the severity of signs and symptoms. 3) When each signs and symptoms were improved in the clinical course, each points were decreased to 1/2, and when disapeared, points evaluated as zero. On these rules, Thiophenicol (a derivative of Chloramphenicol) and placebo were prescribed to 139 cases of acute cystitis and following results were obtained after three days treamtnent. 1) In the group of the drug given appropriately, points decreased from 12.0 to 4.7 in average. 2) In the inapropriate group, points decreased from 11.7 to 7.3. 3) In the placebo group, points decreased from 11.8 to only 8.9.
社団法人日本泌尿器科学会の論文