温度感受性薬剤耐性因子 : II. 宿主細菌細胞からKanamycin耐性因子の温度感受性脱落現象

概要

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A kind of R factor carrying only kanamycin (KM)-resistance marker and originated from a wild strain of Proteus vulgaris was spontaneously eliminated from the host bacterial cells when P. vulgaris (R:KM) was cultured at 42℃, although no elimination occurred in the same bacterial cells grown at 25℃. This thermosensitive elimination of the R (KM) factor was also observed when this R (KM) factor infected the cells of E. coli and Salmonella typhimurium. On the other hand, the ordinary drug-resistance factor could not be eliminated by the cultivation at higher temperatures, even in the same host bacterial cell. From the obtained results, it was considered that this thermosensitive elimination of the R (KM) factor depends upon thermosensitive replication of this R factor.
社団法人日本泌尿器科学会の論文