温度感受性薬剤耐性因子 : I. Kanamycin耐性因子の温度感受性伝達現象

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A strain of Proteus vulgaris isolated from the urinary tract of a patient with postoperative pyelonephritis and resistant to all of sulfonamide (SA), streptomycin (SM), tetracycline (TC) and kanamycin (KM) was found to transfer only its KM-resistance by cell to cell conjugation. The genetic determinant controlling the transferable KM-resistance was considered as a kind of R factor and designated R (KM), since successive transfer of this KM-resistance was also demonstrated from E. coli 20SO received KM-resistance to other substrains of E. coli K-12 or Salmonella typhimurium LT-2, with rather high frequency and in no relation to the sex factor. The transfer of this R (KM) factor was strongly affected by the temperature of the mixing culture in which the conjugation occured. The transfer rate of KM-resistance at 25℃ was about 10^5 times as high as that at 37℃. Thus, a significant thermosensitivity of this R (KM) transfer was confirmed.
社団法人日本泌尿器科学会の論文