バイオコンバージョンによる光学活性ベンジル型アルコール類の生産

概要

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The production of optically pure compounds is of increasing importance in the fine-chemical and commodity-chemical industries. Use of enzymes in stereo- and regiospecific ways is advantageous during the organic synthesis of such products. Optically active benzylic alcohols, which can be employed as chiral building blocks, are obtained by optical resolution, asymmetric reduction, or asymmetric synthesis. Lipases, esterases, and alcohol dehydrogenases are useful for the optical resolution of racemic 1-phenyl-ethanol. Acetophenone is converted to optically pure 1-phenylethanol by asymmetric reduction with yeast and bacterial cells or with alcohol dehydrogenases from these organisms. The reduction is S-specific except for Lactobacillus and Pseudomonas species. Alkylbenzenes are hydroxylated to asymmetric benzylic alcohols by cells of some fungi and a bacterium. This reaction is advantageous because optically pure benzylic alcohols with side-chain lengths of C_2-C_5 can be produced in a one-step reaction. Improvement of the yield is of much practical importance.
社団法人日本生物工学会の論文
2003-10-25