アノイリナーゼ菌(K・A)の代謝に関する研究 : (VI)アノイリナーゼ菌(K・A)のグルタミン酸代謝(2)

概要

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Studies were made, in the point of view of the glutamate metabolism, on the cause of that thiaminase II activity is not observed in B. aneurinolyticus cultivated in the medium containing a large amount of oxymethylpyrimidine (OMP) or thiamine Consequently, it was clarified that the relationship between the thiaminase II activity and glutamate metabolism is due to the action of OMP. The activation of respiratory metabolism of the organism by adding OMP or vitamin B_6 to the medium was again observed, and it has been cleared that the OMP acts as a cofactor in the pathway in which glutamate converts to pyrrolidone carboxylate and then, that vitamin B_6-relating substances act as cofactors in the aerobic metabolism of pyrrolidone carboxylate. The metabolic activity of glutamate of the organism was determined in both of aerobic and anaerobic conditions, and a compensatory difference was observed between the metabolic systems of glutamate and pyrrolidone carboxylate. These results may concern the fact that the largest production of thiaminase II in B. aneurinolyticus is observed in an aerobic culture.
日本ビタミン学会の論文