アノイリナーゼ菌(K・A)の代謝に関する研究 : (V)銅耐性獲得菌体の代謝

概要

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It is well known that Cu^<++> has an inhibitory effect on thiaminase II and causes a significant change of the morphological properties and metabolic systems of B. aneurinolyticus and consequently a Cu^<++>-resistant strain of the organism was obtained. The facts suggest that thiaminase II must play an important role in the metabolism of the organism. In order to clarify this point, comparison was made in a Cu^<++>-containing medium on various properties of the Cu^<++>-resistant and the wild strain. Consequently, a remarkable difference was observed in the glutamate metabolism. Namely, notwithstanding that both of α-ketoglutarate and pyrrolidone carboxylate were formed from glutamate in the wild strain, the latter substance was not obtained in the Cu^<++>-resistant strain. These results likely reveal that thiaminase II concerns an enzymatic system which catalyses the conversion of glutamate to pyrrolidone carboxylate.
日本ビタミン学会の論文