抗微物質に關する研究(第4報)既知合成物質の抗菌作用の比較

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Antimicrobial activities of some synthetic drugs having low toxicity were compared employing about 35 species of microbes as the test organisms. In general, the effectiveness assayed by the serial dilution method was as follows (listed in decreasing order of their activities) : p-phenylphenol (pp), hinokitiol, p-benzylphenol (BP), acid fraction of Thuja oil, hydroxymethyl isopropyl benzene (BIO), benzoi acid, versene (Ver.), sorbic acid (S) (cf. Table 1〜2,page 217).The effect of pH upon antimicrobial activites was listed in Table 3 (page 218). The activity of S and B was increased as the pH of a medium was lowered, but reverse relationship was observed with H. With other drugs, the activities were relatively insensitive to pH-change.Preservative effects of these drugs when applied to soy, "miso" (soy cheese), fruit juice and fish paste, were also criticized (cf. Table 5〜8,page 219〜221). In the case of "miso", phenolic derivatives (PP, BP, BIO, butyl-p-hydroxybenzoate) and Ver. were found to be ineffective, but S as well as dehydroacetic acid (DHA) was effective. In fluit juice, S was effective in the same degree as DHA. Ver. was effective as the preservative for fish paste when applied at a relatively high concentration, and the effectiveness was comparable to that of nitrofurazone (F), but none of other drugs tested were effective.Butyl-p-hydroxybezoate and Ver. when applied to the fish paste in conjunction with F, produced good results in preventing the growth of molds and bacteria.
社団法人日本生物工学会の論文
1955-05-15

抗微物質に關する研究(第4報)既知合成物質の抗菌作用の比較

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