ビタミンCの代謝 : (IV)ヒト赤血球へのAscorbic acid, Isoascorbic acidの取込み

概要

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Comparative studies on the uptake of ascorbic acid (AsA), isoascorbic acid (IAsA) and their oxidized forms (DAsA, DIAsA) by human erythrocytes in vitro were investigated. Reduced forms of AsA and IAsA are uptaken very slowly for long time : AsA is uptaken at the rate of 13% per two hours, while IAsA 20%. Then the rate of the uptake of reduced forms is in proportion to the density out of the erythrocytes (plasma). Oxidized forms entered into the erythrocytes very rapidly as compared with reduced forms, and got in a state of equilibrium within five minutes. DAsA is uptaken at the rate of 50% per five minutes, while DIAsA 40%. The great part of uptaken DAsA and DIAsA was reduced (80%) by the reducing substance of erythrocytes. In plasma the reduced forms are stable. But the oxidized forms are not, because pH of plasma tends to alkaline. In erythrocytes, reduced forms are stable as same as in plasma. Oxidized forms decrease slightly. Probably reduction of DAsA by the erythrocyte will be effective for stabilization of vitamin C.
日本ビタミン学会の論文
1972-04-25