ほ乳類赤血球によるL-アスコルビン酸、D-イソアスコルビン酸の取込み

概要

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The uptake of L-ascorbic acid (L-AsA), D-isoascorbic acid (D-IAsA) and their oxidized forms (L-DAsA. D-DIAsA) by human, monkey, guinea pig, rabbit, sheep and horse erythrocytes in vitro were investigated. Reduced forms of AsA and IAsA are uptaken very slowly for a long time by human, monkey, guinea pig and rabbit erythrocytes ; AsA is uptaken respectively at the rate of 9,9,9,6 % and IAsA is 14,15,21,12 % per two hours. But sheep and horse erythrocytes do not uptake both ASA as well as IAsA. Next, oxidized forms, very different results are got by different species ; that is, oxidized forms are uptaken very rapidly by human and monkey erythrocytes both DAsA and DIAsA, and got in a state of equilibrium within 5〜10 minutes (human erythrocytes uptake 50 % (DAsA), 42 % (DIAsA), monkey 73 % (DAsA), 44 % (DIAsA) after ten minutes) . The great part of uptaken DAsA and DIAsA is reduced (73〜78 %) in the erythrocytes. DAsA is uptaken into guinea pig erythrocytes (19%) as well as in the case of human, monkey, while DIAsA is not uptaken. Then neither DAsA nor DIAsA is uptaken by rabbit, sheep or horse erythrocytes. (Received July 7,1972)
日本ビタミン学会の論文
1972-09-25