CDGP/TS-1による化学療法と放射線治療の同時併用を試みた口腔癌の1例

概要

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Novel anticancer drugs, platinum compound nedaplatin (CDGP) and 5-fluorouracil agent (TS-1), were applied to an oral squamous cell carcinoma patient having tumor located in right buccal mucosa. The tumor was 20 × 30 mm in size. Chemotherapy composed of CDGP 90 mg/m^2 (day 3) and TS-1 100 mg/body (day 1-5), and simultaneous radiation given by 1.8 Gy/day (day 1-5) was carried out. While the effect of this therapy was no change, trismus caused by tumor invasion was obviously ameliorated that had hampered QOL. The side effects were relatively severe : leukocytopenia, neutropenia, thrombocytopenia, and anorexia were grade 3 ; nausea, taste disturbance, and stomatisis were grade 2 ; vomiting was grade 1. The results of this study suggest that this therapy improved the patient's QOL despite severe side effects and is worth evaluating in further accumulated patients.
山口大学医学会の論文
2002-04-30