放射線増感剤RK28システイン抱合体 : その分離と分取について

概要

論文の詳細を見る
We have reported that RK28 cysteine conjugate(metabolite e)might be a novel hypoxic cell radiosensitizer as its concentration in tumor was higher than in serum on the rabbit VX2 tumor system. In this study, we report the results of its isolation and collection from rabbit urine after RK28 intravenous injection. RK28 and major metabolites were analyzed using high performance liquid chromatography(HPLC) with tetrabutylammonium phosphate solution(TBAP). RK28 cysteine conjugate was isolated using a LH20 column, a G10 column, and an ODS column without TBAP. A total amount of 211μg was collected but not enough for further studies.
山口大学医学会の論文
2000-10-31