Genetic and Environmental Factors Affecting Peak Bone Mass in Premenopausal Japanese Women

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概要

• 論文の詳細を見る

• The purpose of this study was to examine the relationships between peak bone mass and genetic and environmental factors. We measured whole-body bone mineral density (BMD), lumbar spine BMD, and radius BMD with dual-energy X-ray absorptiometry (DXA) and analyzed eight genetic factors : vitamin D receptor (VDR)-3', VDR-5', estrogen receptor (ER), calcitonin receptor (CTR), parathyroid hormone (PTH), osteocalcin (OC), apolipoprotein E (ApoE), and fatty acid binding protein 2 (FABP2) allelic polymorphisms using polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLPs). We also surveyed menstrual history, food intake, and history of physical activity using questionnaires. After adjusting for age, body mass index (BMI), current smoking status, current Ca intake, alcohol intake, menoxenia, and physical activity, the mean BMD in subjects with the HH/Hh genotype was significantly higher than that of subjects with the hh genotype for whole-body BMD (mean±SD, 1.20±0.10 vs. 1.18±0.09 g/cm^2 ; HH/Hh vs. hh, p=0.04) and at lumbar spine BMD (mean±SD, 1.18±0.14 vs. 1.14±0.12 g/cm^2 ; HH/Hh vs. hh, p=0.02) in OC allelic polymorphism. Furthermore, the results of multiple regression analyses taking the 8 genetic factors plus the 7 environmental factors listed above into account showed that the strongest factor contributing to BMD was BMI at any site (whole-body and lumbar BMD p<0.0001, radius BMD p=0.0029). In addition, OC polymorphism (p=0.0099), physical activity (p=0.0245), menoxenia (p=0.0384), and PTH polymorphism (p=0.0425) were independent determinants for whole-body BMD, and OC polymorphism (p=0.0137) and physical activity (p=0.0421) were independent determinants for lumbar BMD and radius BMD, respectively.

• 日本衛生学会の論文

著者

• Tomura S

  Department Of Medical Science And Welfare Institute Of Community Medicine University Of Tsukuba

• Tomura Shigeo

  筑波大学 社会医 看護リハ医

• Tomura Shigeo

  Institute Of Community Medicine University Of Tsukuba

• Yanagi Hisako

  筑波大学 社会医 看護リハ医

• Yanagi H

  Department Of Medical Science And Welfare Institute Of Community Medicine University Of Tsukuba

• Yanagi Hisako

  Institute Of Community Medicine University Of Tsukuba

• Hamaguchi Hideo

  Insitute Of Basic Medical Science University Of Tsukuba

• Hamaguchi Hideo

  National Agricultural Research Center

• ENDO Kazue

  Institute of Community Medicine, University of Tsukuba

• HAYAKAWA Yoshika

  Tsukuba International University

• HAYAKAWA Yoshika

  Institute of Community Medicine, University of Tsukuba

• HARA Shuichi

  Institute of Community Medicine, University of Tsukuba

• AMAGAI Hitoshi

  Orthopedics, Department of Physical Therapy, Tsukuba College of Technology

• HAMAGUCHI Hideo

  Institute of Basic Medical Science, University of Tsukuba

• Tomura Shigeo

  Institute Of Community Medicine

• Endo Kazue

  Institute Of Community Medicine University Of Tsukuba

• Hara Shuichi

  Institute Of Community Medicine University Of Tsukuba

• Amagai H

  Tsukuba Coll. Technol. Tsukuba Jpn

• Amagai Hitoshi

  Orthopedics Department Of Physical Therapy Tsukuba College Of Technology

• HAMAGUCHI Hideo

  Institute for Basic Medicine, University of Tsukuba

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