Cognitive Impairment and Nocturnal Blood Pressure Fall in Treated Elderly Hypertensives

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概要

• 論文の詳細を見る

• Objectives: We investigated the association between the fall of nocturnal blood pressure (BP) and cognitive impairment in elderly subjects. Methods: The study was a cross-sectional survey of 204 elderly subjects who had no cerebrovasucular episodes. Ambulatory BP monitoring and assessments of cognitive functions using the Mini-Mental State Examination (MMSE) were performed at the subjects' homes. We classified the subjects treated with antihypertensive drugs into three groups: non-dippers (nocturnal fall <10% of the mean day diastolic BP; n=51), normal dippers (10% to less than 20%; n=58), and extreme dippers (20% or more; n=17). The subjects not treated with antihypertensive drugs were also classified as non-dippers (n=40), normal dippers (n=24), and extreme dippers (n=14). Results: The mean age of participants was 75.2±7.2 years, and 126 (61.7%) were being treated with antihypertensive drugs. In the group of antihypertensive drug users, the number with MMSE≤23 was 30 and the adjusted odds ratio for cognitive impairment in those with an extreme dip in diastolic BP (DBP) was 4.18 (95% CI, 1.07-16.40) in reference to the normal dippers. In contrast, no association was observed between cognitive function and nocturnal BP fall in the group no using antihypertensive drugs. Conclusions: Cognitive impairment was associated with an extreme dip in DBP in the antihypertensive drug users only. It remains to be seen whether careful monitoring of nighttime BP as well as daytime BP may reduce the risk of cognitive impairment in antihypertensive drug users.

• 日本衛生学会の論文

著者

• Okuno Junko

  Department Of Medical Science And Welfare Institute Of Community Medicine University Of Tsukuba

• Okuno Junko

  筑波大学 社会医 看護リハ医

• Tomura S

  Department Of Medical Science And Welfare Institute Of Community Medicine University Of Tsukuba

• Tomura Shigeo

  筑波大学 社会医 看護リハ医

• Yanagi Hisako

  筑波大学 社会医 看護リハ医

• Yanagi H

  Department Of Medical Science And Welfare Institute Of Community Medicine University Of Tsukuba

• Yanagi Hisako

  Institute Of Community Medicine University Of Tsukuba

• Yanagi Hisako

  Department Of Biology Faculty Of Science Shizuoka University

• Okuno Junko

  Department Gastroenterology Kitasato University East Hosipital

• TOMURA Shigeo

  Department of Medical Science and Welfare, Institute of Community Medicine, University of Tsukuba,

• Tomura Shigeo

  Department Of Medical Science And Welfare Institute Of Community Medicine University Of Tsukuba

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