CHANGES IN BONE MINERAL DENSITY DURING SEXUAL MATURATION IN MALE AND FEMALE RATS : CORRELATION WITH SERUM IGF-1, IGFBP-3, OSTEOCALCIN AND SEX STEROIDS

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概要

• 論文の詳細を見る

• Bone(tibia, femur, and lumbar spine)and blood samples were obtained from 100(50 males and 50 females)Wister-Imamichi rats in groups aged 3, 5, 7, 9, 12, 15 and 20 weeks old to investigate the changes in bone mass during puberty in relation to insulin-like growth factor 1(IGF-1), IGF binding protein (IGFBP)-3, osteocalcin(OC)and sex steroids in normal rats. Sharp increases in BMD(bone mineral density)in the tibia, femur and lumbar appeared earlier in female than in male rats, and the BMD in females tended to be higher than in males between 5 and 9 weeks old. After 9 weeks old, BMD in males was higher than that in females, as BMD in males continued to increase whereas that in females tended to remain in a steady state after this stage. This sex-related difference in changes in BMD pattern is probably related to the serum concentrations of IGF-1, IGFBP-3, testosterone, and 17β-estradiol with maturation. In males, marked increases in serum IGF-1 and IGFBP-3 concentrations appeared earlier than that in serum testosterone level. IGF-1 and testosterone peaked at 9 weeks of age, and thereafter remarked in a steady state, whereas IGFBP-3 reached a peak at 7 weeks of age, and then declined gradually. In females, the changes in patterns of serum 17β-estradiol, IGF-1, and IGFBP-3 levels were very similar. The levels increased gradually from 3〜5 weeks old, peaked at 9 weeks, and then decreased slowly thereafter. In contrast, serum OC concentrations remain relatively high from 3 to 9 and from 3 to 7 weeks old in males and females, respectively, although OC in both sexes declined gradually with aging. These observations suggest that BMD development occurs earlier in female than in male rats. This sex-related difference in changes in the BMD pattern may result from the earlier onset of puberty in females, and from the sex-specific differences in concentrations of IGF-1, IGFBP-3 and sex steroids with maturation.

• 日本体力医学会の論文
• 1998-02-01

著者

• Mukai N

  Univ. Tsukuba Tsukuba Jpn

• Usuki Satoshi

  筑波大学臨床医学系産科婦人科

• Mukai Naoki

  筑波大学体育科学系

• Fukuda Rika

  筑波大学大学院博士課程体育科学研究科

• Amagai H

  Tsukuba Coll. Technol. Tsukuba Jpn

• Amagai Hitoshi

  Orthopedics Department Of Physical Therapy Tsukuba College Of Technology

• Hayashi K

  Study Group Of Sport Nutrition Tokyo

• KOTANI ERI

  筑波大学臨床医学系産科婦人科

• AMAGAI HITOSHI

  筑波技術短期大学視覚部理学療法学科整形外科

• HAYASHI KOICHIRO

  筑波大学臨床医学系整形外科

• TAKAMATSU KAORU

  筑波大学体育科学系

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• CHANGES IN BONE MINERAL DENSITY DURING SEXUAL MATURATION IN MALE AND FEMALE RATS : CORRELATION WITH SERUM IGF-1, IGFBP-3, OSTEOCALCIN AND SEX STEROIDS
• DO SERUM IGF-I AND IGFBP-3 LEVELS REFLECT THE INCREMENT OF BONE MASS THROUGH RUNNING TRAINING IN FEMALE RATS?

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