走運動ストレス時の視床下部 ACTH 分泌調節因子 (CRH) の動態

概要

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Running becomes a stress if it persists above the lactate threshold (LT) and results in enhanced plasma ACTH level. ACTH release is controlled by CRH and AVP. AVP would have critical role rather than CRH in the running stress-induced ACTH release. We already reported that running stress induce decrease of the AVP content in the stalk median eminence (SME) which mean AVP secretion into the pituitary portal vein. However, it is unknown whether running stress increases CRH secretion into the pituitary portal vein. To address it, we investigate whether the CRH content in the SME would decrease during the running stress. Adult male wistar rats were previously habituated to running and then subjected to a 30-min running test above the LT. The brains were removed and subjected to enzyme immunoassay for the SME-CRH and SME-AVP content. The SME-CRH content was unchanged, while the SME-AVP reduced after the running test (from the previous study). The ratio of AVP to CRH contents, therefore, reduced significantly during the running test. These results suggest that CRH secretion into the portal blood dose not increase, and even if not so, it secretory manner into the pituitary portal blood would be different from that of AVP during running stress.
日本運動生理学会の論文
2005-02-25