遊泳運動ストレスによる脳内オレキシン神経の活性化

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Orexin (OX) neurons originating in the lateral hypothalamic area (LHA) is known to play a provocative role in several key physiological functions, in regulating feeding, arousal, locomotor activity and sleep-wake cycle. OX also would play a stimulatory role for stress response, probably through acting on the hypothalamus. The stress, including swimming exercise, induces c-Fos accumulation in the parvocellular part of the paraventricular hypothalamic nucleus (pPVN), suggesting some role of OX in regulating its stress response. However, it is not uncertain whether exercise activates OX neurons and OX contributes on the stress response. Swimming exercise has been established in laboratory rodents, which rats were accustomed to swimming previously. To examine this issue, Wistar male rats were subjected to an acute and/or repeated swimming (swimming exercise). Brains from those rats were prepared for immunohistochemistry for Fos. Fos accumulation increased in the OX-containing neuron, and also in the parvocellular part of the PVN, which is most responsive region to stress, in response to acute 10 min of acute swimming. Increment of Fos accumulation in OX-containing neurons and in the pPVN also occur in rats underwent repeated swimming challenges, although their responsiveness was significantly reduced. The reduced rate was significantly greater in the PVN than that in the LHA (OX-containing neurons). These results show that OX-containing neurons activate with acute swimming and its responsiveness would be kept even though swimming has prior done repeatedly for a week. Thus, OX neurons would activate not only with acute swimming, but also swimming exercise.
2006-02-28

遊泳運動ストレスによる脳内オレキシン神経の活性化

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